Journal article
Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides
The Medical clinics of North America, v 95(4), pp 819-842
Jul 2011
PMID: 21679793
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This article reviews three classes of antibacterial agents that are uncommonly used in bacterial infections and therefore can be thought of as special-use agents. The polymyxins are reserved for gram-negative bacilli that are resistant to virtually all other classes of drugs. Rifampin is used therapeutically, occasionally as a companion drug in treatment of refractory gram-positive coccal infections, especially those involving foreign bodies. Rifaximin is a new rifamycin that is a strict enteric antibiotic approved for treatment of traveler's diarrhea and is showing promise as a possible agent for refractory Clostridium difficile infections. The aminoglycosides are used mainly as companion drugs for the treatment of resistant gram-negative bacillary infections and for gram-positive coccal endocarditis.
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Details
- Title
- Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides
- Creators
- Luke F Chen - Duke UniversityDonald Kaye - Drexel University
- Publication Details
- The Medical clinics of North America, v 95(4), pp 819-842
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:000292619700009
- Scopus ID
- 2-s2.0-79958804423
- Other Identifier
- 991019168866604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology