Journal article
Cutaneous Manifestations of Scleroderma
Journal of the Dermatology Nurses' Association, v 15(2), pp 86-96
01 Mar 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Scleroderma is a rare, female predominant clinically heterogenous, autoimmune condition characterized by the presence of autoantibodies, vascular abnormalities, and fibrosis. Skin thickening as a result of fibrosis is a hallmark clinical finding, and the extent of this skin thickening further classifies clinical subsets of scleroderma. Organ systems affected may include pulmonary (interstitial lung disease, pulmonary arterial hypertension), renal (scleroderma renal crisis), gastrointestinal (dysmotility, reflux esophagitis, gastric antral vascular ectasia), cardiac (arrhythmias, cardiac fibrosis), and musculoskeletal (arthritis, contractures). Raynaud phenomenon and telangiectasis occur as a result of vascular involvement. Diagnostic workup requires a thorough history and physical examination, supplemented by autoantibody testing. No single therapeutic agent is indicated to treat all manifestations of scleroderma. Rather, system- or organ-based treatment is indicated. Not only are skin manifestations often the presenting feature of scleroderma, progressive skin changes carry prognostic implications, underscoring the value of dermatology insight for early diagnosis suspicion, referral to rheumatology, and timely management.
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Details
- Title
- Cutaneous Manifestations of Scleroderma
- Creators
- Manushi Aggarwal - Loma Linda UniversityVaneet Kaur Sandhu - Loma Linda University
- Publication Details
- Journal of the Dermatology Nurses' Association, v 15(2), pp 86-96
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000971952200007
- Scopus ID
- 2-s2.0-85150434687
- Other Identifier
- 991022046552404721
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- Web of Science research areas
- Dermatology