Journal article
Cutaneous T-cell lymphoma in association with silicone breast implants
Journal of the American Academy of Dermatology, v 32(6), pp 939-942
1995
PMID: 7751462
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background:
Cutaneous T-cell lymphoma (CTCL) is a chronic malignancy of helper T cells with the CD4 phenotype. It occurs less frequently in young women but is increasing in incidence for unknown reasons. Silicone breast implants have been associated with T-cell-mediated autoimmune reactions.
Objective:
Our purpose was to suggest the hypothesis that CTCL may arise after breast implants and that different patients with CTCL may be stimulated by different antigens.
Methods:
Investigators with many patients with CTCL were queried regarding the occurrence of CTCL in women after breast implants.
Results:
Three cases of confirmed CTCL after breast implants were identified and are reported. In one patient with Sézary syndrome and CTCL, the disease went into remission after removal of implants, resolution of chronic staphylococcal infection, and initiation of photopheresis and interferon alfa therapy. Another patient had progressive disease.
Conclusion:
CTCL may occur in association with breast implants in young female patients, but causality is unknown. If CTCL is antigen driven, then it is likely to result from several different antigens in different groups of patients.
Metrics
Details
- Title
- Cutaneous T-cell lymphoma in association with silicone breast implants
- Creators
- Madeleine Duvic - The University of Texas MD Anderson Cancer CenterDennis Moore - The University of Texas MD Anderson Cancer CenterAlan Menter - Baylor University Medical CenterEric C Vonderheid - Drexel UniversityDenise Moore - Pediatrics
- Publication Details
- Journal of the American Academy of Dermatology, v 32(6), pp 939-942
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:A1995RA34400002
- Scopus ID
- 2-s2.0-0029000912
- Other Identifier
- 991019184040504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology