Journal article
Cutaneous squamous cell carcinoma of the lip: A population‐based analysis
The Laryngoscope, v 128(1), pp 84-90
Jan 2018
PMID: 28573764
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives/Hypothesis
The role of cumulative ultraviolet (UV) radiation in cutaneous squamous cell carcinoma of the lip (CSCCL) is well understood. This study seeks to evaluate overall survival as well as incidence and demographics across geographic regions, given differences in UV exposure across the United States.
Study Design
Retrospective population‐based analysis.
Methods
A total of 14,901 CSCCL cases were identified as being from the West, Midwest, South, or Northeast, utilizing the Surveillance, Epidemiology, and End Results registry from 1973 to 2013. Demographics, stage of disease, and treatment modalities were compared among regions.
Results
Of the CSCCL cases reported, 58.3%, 24.5%, 10.8%, and 6.4% originated from the West, Midwest, South, and Northeast, respectively. Patients most commonly presented with T1 tumors (81.3%), and nodal and distant metastasis was rare for patients from all regions (3.1% and 0.3%, respectively). Patients with American Joint Committee on Cancer stage II and higher were most likely from the Northeast or South. Overall, most patients were treated with surgery monotherapy (89.5%); however, surgical monotherapy was least commonly utilized in patients in the Northeast and South. Overall 5‐year disease specific survival was measured at 94.7%.
Conclusion
Although areas of high UV index are implicated in increased morbidity and mortality due to CSCCL, this study indicates that a variety of factors play a role in CSCCL incidence and outcomes in the United States. The elderly and non‐white populations were identified as poor prognostic demographic factors. Investigation detailing differences in CSCCL detection and treatment may aid in the identification of higher‐risk populations.
Level of Evidence
4. Laryngoscope, 128:84–90, 2018
Metrics
Details
- Title
- Cutaneous squamous cell carcinoma of the lip: A population‐based analysis
- Creators
- Aykut A. Unsal - Rowan UniversityAylin B. Unsal - Rutgers, The State University of New JerseyTara E. Henn - Rutgers, The State University of New JerseySoly Baredes - Rutgers, The State University of New JerseyJean Anderson Eloy - Rutgers, The State University of New Jersey
- Publication Details
- The Laryngoscope, v 128(1), pp 84-90
- Publisher
- Wiley
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000418424600022
- Scopus ID
- 2-s2.0-85020137744
- Other Identifier
- 991021965456504721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Otorhinolaryngology