Journal article
Cutting Edge: T Cells from Aged Mice Are Resistant to Depletion Early During Virus Infection
The Journal of immunology (1950), v 171(7), pp 3353-3357
01 Oct 2003
PMID: 14500628
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract Aging is associated with decreased expansion of T cells upon stimulation. In young mice, infection induces a transient T cell depletion followed by the development of an Ag-specific T cell response that controls the infection. We found that T cells were depleted early after infection with E55 + murine leukemia retrovirus in young, but not aged, mice. Adoptive transfer experiments showed donor T cells of young, but not aged, mice were depleted due to apoptosis in various tissues of young recipients. However, T cells of neither young nor aged donors were depleted in aged recipients. These results indicate that both environmental and intrinsic cellular properties limit depletion of T cells of aged mice and suggest a novel explanation for the decreased T cell response associated with aging.
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Details
- Title
- Cutting Edge: T Cells from Aged Mice Are Resistant to Depletion Early During Virus Infection
- Creators
- Jiu Jiang - BiparFarvardin Anaraki - BiparKenneth J. BlankDonna M. Murasko - Drexel University
- Publication Details
- The Journal of immunology (1950), v 171(7), pp 3353-3357
- Publisher
- American Association of Immunologists (AAI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Biology
- Web of Science ID
- WOS:000185548000007
- Scopus ID
- 2-s2.0-0141955151
- Other Identifier
- 991020950550204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology