Journal article
Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice
The Journal of immunology (1950), v 182(4), pp 1789-1793
15 Feb 2009
PMID: 19201829
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Multiple sclerosis is a sexually dimorphic, demyelinating disease of the CNS, and experimental allergic encephalomyelitis (EAE) is its principal autoimmune model. Young male SJL/J mice are relatively resistant to EAE whereas older males and SJL/J females of any age are susceptible. By comparing a wide age range of proteolipid protein peptide 139-151 immunized mice, we found that female disease severity remains constant with age. In contrast, EAE disease severity increases with age in SJL/J males, with young males having significantly less severe disease and older males having significantly more disease than equivalently aged females. To determine whether the Y chromosome contributes to this sexual dimorphism, EAE was induced in consomic SJL/J mice carrying a B10.S Y chromosome (SJL.Y(B10.S)). EAE was significantly more severe in young male SJL.Y(B10.S) mice compared with young male SJL/J mice. These studies show that a Y chromosome-linked polymorphism controls the age-dependent EAE sexual dimorphism observed in SJL/J mice.
Metrics
Details
- Title
- Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice
- Creators
- Karen M Spach - Department of Medicine, University of Vermont, Burlington, VT 05405, USAMelissa BlakeJanice Y BunnBen McElvanyRajkumar NoubadeElizabeth P BlankenhornCory Teuscher
- Publication Details
- The Journal of immunology (1950), v 182(4), pp 1789-1793
- Publisher
- American Association of Immunologists (AAI); United States
- Grant note
- R01 NS036526-11 / NINDS NIH HHS R01 NS060901 / NINDS NIH HHS R01 NS036526-08 / NINDS NIH HHS R01 NS036526-03 / NINDS NIH HHS R01 NS036526 / NINDS NIH HHS R01 NS036526-04A1 / NINDS NIH HHS NS060901 / NINDS NIH HHS R01 NS036526-06 / NINDS NIH HHS R01 NS036526-09A1 / NINDS NIH HHS R01 NS036526-01 / NINDS NIH HHS NS36526 / NINDS NIH HHS R01 NS060901-01A1 / NINDS NIH HHS R01 NS061014-02 / NINDS NIH HHS R01 NS036526-08S1 / NINDS NIH HHS R01 NS036526-05 / NINDS NIH HHS R01 NS060901-02 / NINDS NIH HHS R01 NS036526-10 / NINDS NIH HHS R01 NS036526-04A1S1 / NINDS NIH HHS R01 NS061014 / NINDS NIH HHS R01 NS036526-12 / NINDS NIH HHS R01 NS061014-01 / NINDS NIH HHS R01 NS036526-07 / NINDS NIH HHS NS061014 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000263126300004
- Scopus ID
- 2-s2.0-61449191655
- Other Identifier
- 991014878103904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology