Journal article
Cyclic AMP phosphodiesterase activity of murine T and B lymphocytes
Cellular immunology, v 41(2), pp 421-426
Dec 1978
PMID: 215333
Abstract
Recent evidence suggests that adenosine 3′,5′-monophosphate (cyclic AMP) may play a role in lymphocyte responses. The nature of this role is yet unclear since it has been reported that increases in intracellular cyclic AMP can both inhibit and enhance immune functions. In an attempt to determine how lymphocyte cyclic AMP metabolism is regulated we have measured cyclic nucleotide phosphodiesterase in populations of murine T and B lymphocytes. Results indicate that the enzyme activity in B cells was over fourfold higher than that found in thymocytes. Further analyses by preparative polyacrylamide gel electrophoresis revealed that these cell populations contained different multiple forms of the enzyme.
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Details
- Title
- Cyclic AMP phosphodiesterase activity of murine T and B lymphocytes
- Creators
- Richard Winchurch - Drexel UniversityWilliam Hait - Drexel UniversityBenjamin Weiss - Drexel University
- Publication Details
- Cellular immunology, v 41(2), pp 421-426
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1978GC53000020
- Scopus ID
- 2-s2.0-0018251273
- Other Identifier
- 991020836357904721