Metalated nitriles are nucleophilic chameleons whose precise identity is determined by the nature of the metal, the solvent, the temperature, and the structure of the nitrile. The review surveys the different structural types and their cyclization trajectories to show how to selectively tune the metalated nitrile geometry for stereoselective cyclizations to a variety of cis or trans hydrindanes, decalins, and bicyclo[4.3.0]undecanes.( (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Cyclic Metalated Nitriles: Stereoselective Cyclizations to cis- and trans-Hydrindanes, Decalins, and Bicyclo[4.3.0]undecanes
Creators
Fraser F. Fleming - Duquesne University
Subramanyham Gudipati - Schering Plough Res Inst, Kenilworth, NJ 07033 USA
Publication Details
European journal of organic chemistry, v 2008(32), pp 5365-5374
Publisher
Wiley
Number of pages
10
Grant note
R15AI051352 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
National Science Foundation (NSF)
Resource Type
Journal article
Language
English
Academic Unit
Chemistry
Web of Science ID
WOS:000261756900001
Scopus ID
2-s2.0-57349110218
Other Identifier
991020898393704721
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