Journal article
Cyclic alkenenitriles: chemoselective oxonitrile cyclizations
Journal of organic chemistry, v 67(26), pp 9414-9416
27 Dec 2002
PMID: 12492346
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Potassium tert-butoxide triggers the chemoselective cyclization between nitrile anions and remote, enolizable carbonyl groups, despite the acidity difference favoring enolate formation and addition to the nitrile group. Domino deprotonation, cyclization, and dehydration efficiently transform a diverse array of omega-oxonitriles into carbocyclic and heterocyclic five- and six-membered alkenenitriles in a single synthetic operation.
Metrics
8 Record Views
Details
- Title
- Cyclic alkenenitriles: chemoselective oxonitrile cyclizations
- Creators
- Fraser F Fleming - Duquesne UniversityLee A Funk - Duquesne UniversityRamazan Altundas - Duquesne UniversityVaqar Sharief - Duquesne University
- Publication Details
- Journal of organic chemistry, v 67(26), pp 9414-9416
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000180072300037
- Other Identifier
- 991020898495904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Organic