Journal article
Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer
Nature communications, v 4(1), pp 2812-2812
01 Nov 2013
PMID: 24287487
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates the pRB protein and promotes G(1)/S cell-cycle progression and oncogenesis. Dicer is a central regulator of miRNA maturation, encoding an enzyme that cleaves double-stranded RNA or stem-loop-stem RNA into 20-25 nucleotide long small RNA, governing sequence-specific gene silencing and heterochromatin methylation. The mechanism by which the cell cycle directly controls the non-coding genome is poorly understood. Here we show that cyclin D1(-/-) cells are defective in pre-miRNA processing which is restored by cyclin D1a rescue. Cyclin D1 induces Dicer expression in vitro and in vivo. Dicer is transcriptionally targeted by cyclin D1, via a cdk-independent mechanism. Cyclin D1 and Dicer expression significantly correlates in luminal A and basal-like subtypes of human breast cancer. Cyclin D1 and Dicer maintain heterochromatic histone modification (Tri-m-H3K9). Cyclin D1-mediated cellular proliferation and migration is Dicer-dependent. We conclude that cyclin D1 induction of Dicer coordinates microRNA biogenesis.
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Details
- Title
- Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer
- Creators
- Zuoren Yu - Thomas Jefferson UniversityLiping Wang - Thomas Jefferson UniversityChenguang Wang - Thomas Jefferson UniversityXiaoming Ju - Thomas Jefferson UniversityMin Wang - Thomas Jefferson UniversityKe Chen - Thomas Jefferson UniversityEmanuele Loro - Thomas Jefferson UniversityZhiping Li - Thomas Jefferson UniversityYuzhen Zhang - Yangpu Hospital of Tongji UniversityKongming Wu - Thomas Jefferson UniversityMathew C. Casimiro - Thomas Jefferson UniversityMichael Gormley - Thomas Jefferson UniversityAdam Ertel - Thomas Jefferson UniversityPaolo Fortina - Thomas Jefferson UniversityYihan Chen - Yangpu Hospital of Tongji UniversityAydin Tozeren - Drexel UniversityZhongmin Liu - Yangpu Hospital of Tongji UniversityRichard G. Pestell - Thomas Jefferson University
- Publication Details
- Nature communications, v 4(1), pp 2812-2812
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- R01CA070896; R01CA075503; R01CA132115; R01CA107382; R01CA086072 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 81172515 / NSFC; National Natural Science Foundation of China (NSFC) 2012CB966800 / National Basic Research Program of China P30CA056036 / Kimmel Cancer Center NIH Cancer Center Core Dr. Ralph and Marian C. Falk Medical Research Trust Pennsylvania Department of Health R01CA086072 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Decision Sciences (and Management Information Systems); School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000328026200002
- Scopus ID
- 2-s2.0-84889256981
- Other Identifier
- 991019167962304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology