Journal article
Cyclohexylcarbonitriles: diastereoselective arylations with TMPZnClLiCl
Journal of organic chemistry, Vol.77(17), p7671
07 Sep 2012
Abstract
Deprotonating substituted cyclohexanecarbonitriles with TMPZnCl*LiCl is used to generate zincated nitriles that diastereoselectively couple with aryl bromides in the presence of catalytic Pd[(OAc).sub.2] and S-Phos. The unusual diastereoselectivity trends observed for the generated nitriles could have important implication for synthesizing substituted cyclohexanecarbonitrile-containing pharmaceuticals.
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Details
- Title
- Cyclohexylcarbonitriles: diastereoselective arylations with TMPZnClLiCl
- Creators
- Robert J MyckaStephanie DuezSebastian BernhardtJohannes HeppekausenPaul KnochelFraser F Fleming
- Publication Details
- Journal of organic chemistry, Vol.77(17), p7671
- Publisher
- American Chemical Society
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Identifiers
- 991020898497604721