Journal article
Cyclooxygenase metabolites in human lung anaphylaxis: airway vs. parenchyma
Journal of applied physiology: respiratory, environmental and exercise physiology, v 53(3), pp 589-595
Sep 1982
PMID: 6813301
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We studied the generation of arachidonic acid cyclooxygenase metabolites (AACMs) during in vitro anaphylaxis of passively sensitized human lung parenchymal and airway fragments. Prostaglandins E, F2 alpha, D2, 6-keto-prostaglandin F1 alpha, and thromboxane B2 (PGE, PGF2 alpha, PGD2, 6-keto-PGF1 alpha, TXB2, respectively) were assayed by radioimmunoassay. Results with airway tissue were compared with subpleural parenchymal fragments from the same lungs similarly challenged. Spontaneous generation of prostacyclin (PGI2), as measured by its stable metabolite 6-keto-PGF1 alpha, exceeded by two- to threefold other spontaneous AACM release in both bronchial and parenchymal fragments. In airway antigen produced variable AACM responses, but in general the rank order was 6-keto-PGF1 alpha greater than PGE congruent to PGF2 alpha greater than PGD2 greater than TXB2. The rank for antigen-induced AACM release from parenchyma was 6-keto-PGF1 alpha congruent to PGD2 much greater than PGF2 alpha greater than TXB2 congruent to PGE. In airway, as in parenchyma, very little AACM production during anaphylaxis can be attributed to smooth muscle contraction per se. Histamine released from bronchi (0.67 +/- 0.30 micrograms/g lung) was significantly less than from parenchyma (3.7 +/- 0.70 micrograms/g) despite comparable histamine content. At comparable levels of histamine release, the parenchyma produced greater quantities than bronchi of all AACMs except PGE. The comparatively limited bronchial capacity to generate PGF2 alpha, PGD2, TXB2, and histamine (airway constrictors) along with predominant generation of PGI2 and PGE (airway relaxants) may help preserve airway patency.
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Details
- Title
- Cyclooxygenase metabolites in human lung anaphylaxis: airway vs. parenchyma
- Creators
- E S SchulmanN F Adkinson, JrH H Newball
- Publication Details
- Journal of applied physiology: respiratory, environmental and exercise physiology, v 53(3), pp 589-595
- Publisher
- American Physiological Society (APS); United States
- Grant note
- HL-24210 / NHLBI NIH HHS HL-07159 / NHLBI NIH HHS HL-24938 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:A1982PG07800008
- Scopus ID
- 2-s2.0-0019959276
- Other Identifier
- 991014878091804721
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- Web of Science research areas
- Physiology
- Sport Sciences