Journal article
Cystic fibrosis and pregnancy in the modem era: A case control study
Journal of cystic fibrosis, v 13(1), pp 69-73
01 Jan 2014
PMID: 24018176
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Increasingly, women with cystic fibrosis become pregnant. Outcomes of these women need further study particularly in the setting of improved survival in CF.
Methods: We performed a case-control study of pregnant CF women including 22 matched pairs with an average follow-up of 4.5 years. Nutritional outcomes, changes in lung function, and exacerbation rates were compared.
Results: Matched pairs were similar in age, sweat chloride, FEV1. and FVC % predicted, BMI, and diabetes status. Change in BMI, FEV1 and FVC % predicted at the end of pregnancy and at last follow-up were similar between groups. Moreover, rates of exacerbation before, during and after pregnancy were similar. On multivariable analysis pregnancy had no effect on change in lung function over the study period. Significant predictors of decline included higher pre-pregnancy lung function and pancreatic insufficiency.
Conclusions: Pregnancy does not lead to immediate or medium-term adverse effects for CF patients. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
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Details
- Title
- Cystic fibrosis and pregnancy in the modem era: A case control study
- Creators
- Monica Ahluwalia - Supreme Council Of HealthJeffrey B. Hoag - Cancer Treatment Centers of AmericaAnas Hadeh - Drexel UniversityMarianne Ferrin - University of PennsylvaniaDenis Hadjiliadis - University of PennsylvaniaVance G Nielsen
- Publication Details
- Journal of cystic fibrosis, v 13(1), pp 69-73
- Publisher
- Elsevier
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000329951600011
- Scopus ID
- 2-s2.0-84890359749
- Other Identifier
- 991019357776004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Respiratory System