Journal article
Cytokine production after influenza vaccination in a healthy elderly population
Vaccine, v 16(18), pp 1722-1731
1998
PMID: 9778748
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Influenza vaccination is less efficacious in the elderly than in the young. To characterize this age-related decrease in immune response to influenza vaccination, antibody and cell-mediated responses to influenza vaccine were assessed before immunization and 4 weeks after vaccination of a population of 270 healthy elderly individuals (mean age: 80.2 years) living in eight local continuing care retirement communities (CCRCs) and 30 young individuals (mean age: 27.8 years). The antibody titres produced against all three influenza strains increased significantly after vaccination in both the young and elderly (
p<0.0005); however, the young demonstrated significantly higher titres to all three strains than did the elderly (
p<0.03). Peripheral blood mononuclear cells (PBMC) cultured with influenza vaccine demonstrated significantly increased proliferation (elderly:
p<0.00005; young:
p<0.001) after vaccination, with proliferative responses in the young significantly higher than the elderly both before (
p<0.04) and after (
p<0.0005) vaccination. Similarly, IFNγ production in these PBMC cultures increased significantly pre- to postvaccination in both young and elderly (young:
p<0.006; elderly:
p<0.00005), but the young produced more than the elderly both pre- and postvaccination (
p<0.0001). Following vaccination, PBMC production of IL-10 was higher in the young than in the elderly (
p<0.0015), while IL-6 production was comparable in both young and elderly individuals. Greater than 13% of the elderly population did not produce detectable IL-6, IL-10, or IFNγ either before or after vaccination. The data show that the decreased cell-mediated and humoral responses to influenza vaccination of this healthy elderly population are accompanied by the production of lower levels of cytokines. A unique finding in this population of 270 healthy elderly was the association between a T
HO cytokine profile and intact immune responses to influenza vaccine. A similar relationship was not seen in the young.
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Details
- Title
- Cytokine production after influenza vaccination in a healthy elderly population
- Creators
- Erica D BernsteinElizabeth M GardnerElias AbrutynPeter GrossDonna M Murasko
- Publication Details
- Vaccine, v 16(18), pp 1722-1731
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000076052900007
- Scopus ID
- 2-s2.0-0032212474
- Other Identifier
- 991014878592004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental