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Cytokine profiling: variation in immune modulation with preterm birth vs. uncomplicated term birth identifies pivotal signals in pathogenesis of preterm birth
Journal article   Open access   Peer reviewed

Cytokine profiling: variation in immune modulation with preterm birth vs. uncomplicated term birth identifies pivotal signals in pathogenesis of preterm birth

Jeffrey M. Denney, Edward Nelson, Pathick Wadhwa, Thaddeus Waters, Leny Mathew, Robert L. Goldenberg and Jennifer F. Culhane
Journal of perinatal medicine, v 49(3), pp 299-309
01 Mar 2021
PMID: 33035192
url
https://www.degruyter.com/document/doi/10.1515/jpm-2020-0025/pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1515/jpm-2020-0025View
Published, Version of Record (VoR) Open

Abstract

Life Sciences & Biomedicine Obstetrics & Gynecology Pediatrics Science & Technology
Objectives: To assess deviations in longitudinally measured cytokines with preterm birth (PTB). Methods: Prospective longitudinal study targeting 80 subjects. Phlebotomy specimens for broad panel of cytoldne analysis were obtained at three time (T) intervals: first trimester (T1: 8-14 weeks' gestation), second trimester (T2: 18-22 weeks' gestation), and third trimester (T3: 28-32 weeks' gestation). Important demographics and outcomes were tracked. Data were stratified and the target groups were analyzed as follows: "Uncomplicated" (delivered 37 weeks) or "Preterm Birth" (<37 weeks). Generalized Linear Modeling determined rate of change T1-T3 by outcome. Results: Complete data replete with phlebotomy at all three visits were obtained on 80 women. Birth outcomes were as follows: 11 Uncomplicated Term Birth (UTB), 28 PTB, 4 low birth weight (LBW), 16 OB complications (OBC), 11 current infections (IFN), and 10 mixed complications (MC=2 or more of the above). 28 PTB were compared to 11 uncomplicated term deliveries. In both groups, T helper type 1 (TH1) cytoldne (IL-1 beta), pleiotrophic pro-inflammatory cytoldne (IL-6), and counter-regulatory cytoldne (IL-10) responses decreased over gestation, but rates of change in IL-1 beta, IL-6, and IL-10 were significantly different. Stratification of women by smoking status additionally demonstrated significant variance in immune status over the course of pregnancy Conclusions: Women delivering PTB demonstrated significant differences in cytokine trajectory over pregnancy; these data further validate key role played by immune regulation in directing pregnancy outcome. Likewise, smoking impacts longitudinal trajectory of cytoldnes over pregnancy.

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Collaboration types
Domestic collaboration
Web of Science research areas
Obstetrics & Gynecology
Pediatrics
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