Journal article
Cytokine profiling: variation in immune modulation with preterm birth vs. uncomplicated term birth identifies pivotal signals in pathogenesis of preterm birth
Journal of perinatal medicine, v 49(3), pp 299-309
01 Mar 2021
PMID: 33035192
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: To assess deviations in longitudinally measured cytokines with preterm birth (PTB).
Methods: Prospective longitudinal study targeting 80 subjects. Phlebotomy specimens for broad panel of cytoldne analysis were obtained at three time (T) intervals: first trimester (T1: 8-14 weeks' gestation), second trimester (T2: 18-22 weeks' gestation), and third trimester (T3: 28-32 weeks' gestation). Important demographics and outcomes were tracked. Data were stratified and the target groups were analyzed as follows: "Uncomplicated" (delivered 37 weeks) or "Preterm Birth" (<37 weeks). Generalized Linear Modeling determined rate of change T1-T3 by outcome.
Results: Complete data replete with phlebotomy at all three visits were obtained on 80 women. Birth outcomes were as follows: 11 Uncomplicated Term Birth (UTB), 28 PTB, 4 low birth weight (LBW), 16 OB complications (OBC), 11 current infections (IFN), and 10 mixed complications (MC=2 or more of the above). 28 PTB were compared to 11 uncomplicated term deliveries. In both groups, T helper type 1 (TH1) cytoldne (IL-1 beta), pleiotrophic pro-inflammatory cytoldne (IL-6), and counter-regulatory cytoldne (IL-10) responses decreased over gestation, but rates of change in IL-1 beta, IL-6, and IL-10 were significantly different. Stratification of women by smoking status additionally demonstrated significant variance in immune status over the course of pregnancy
Conclusions: Women delivering PTB demonstrated significant differences in cytokine trajectory over pregnancy; these data further validate key role played by immune regulation in directing pregnancy outcome. Likewise, smoking impacts longitudinal trajectory of cytoldnes over pregnancy.
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Details
- Title
- Cytokine profiling: variation in immune modulation with preterm birth vs. uncomplicated term birth identifies pivotal signals in pathogenesis of preterm birth
- Creators
- Jeffrey M. Denney - Wake Forest UniversityEdward Nelson - University of California, IrvinePathick Wadhwa - University of California, IrvineThaddeus Waters - Drexel UniversityLeny Mathew - Children's Hospital of PhiladelphiaRobert L. Goldenberg - Drexel UniversityJennifer F. Culhane - Yale University
- Publication Details
- Journal of perinatal medicine, v 49(3), pp 299-309
- Publisher
- Walter De Gruyter
- Number of pages
- 11
- Grant note
- R01 HD-041696; PO1 HD047609 / US PHS (NIH); United States Department of Health & Human Services; United States Public Health Service; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000626597700006
- Scopus ID
- 2-s2.0-85094964542
- Other Identifier
- 991019339701104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics