Journal article
Cytokine recognition by human interleukin 5 receptor
Vitamins and hormones, v 71, pp 321-344
2005
PMID: 16112273
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The activation of interleukin 5 (IL-5) receptor is a dynamic process that depends on specific interaction of IL-5 with IL-5 receptor alpha, the formation of oligomeric receptor complexes with receptor beta, and the initiation of cytoplasmic phosphorylation events. These steps culminate in the triggering of a cellular response. Important advances have been made recently in understanding the molecular mechanisms of cytokine recognition, receptor assembly, and signal triggering. Cytokine recognition can be envisioned by relating structure to function in IL-5 and IL-5 receptor alpha. A pair of charge-complementary regions plays an essential role in the specific interaction between IL-5 receptor alpha and IL-5. Moreover, peptide library methodology has led to the discovery of IL-5 receptor alpha antagonists that mimic key elements in IL-5 receptor recognition. Because IL-5 has been implicated in the pathology of eosinophil-related inflammatory diseases, revealing the key recognition elements of IL-5, IL-5 mimetic peptides, and IL-5 receptor alpha could help drive the design of new compounds for therapeutic treatment against allergic inflammatory diseases such as asthma.
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Details
- Title
- Cytokine recognition by human interleukin 5 receptor
- Creators
- Tetsuya Ishino - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USANoreen RobertsonIrwin Chaiken
- Publication Details
- Vitamins and hormones, v 71, pp 321-344
- Publisher
- Elsevier; United States
- Grant note
- R01-GM55648 / NIGMS NIH HHS R01-AI40462 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; SOM Dean - Research Administration
- Web of Science ID
- WOS:000232368000011
- Scopus ID
- 2-s2.0-27744453929
- Other Identifier
- 991014878255104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism