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Journal article
Cytokines Associated With Bronchopulmonary Dysplasia or Death in Extremely Low Birth Weight Infants
Pediatrics (Evanston), v 123(4), pp 1132-1141
01 Apr 2009
PMID: 19336372
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE. The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days.
METHODS. For 1067 extremely low birth weight infants in the Neonatal Research Network of the National Institute of Child Health and Human Development, levels of 25 cytokines were measured in blood collected within 4 hours after birth and on days 3, 7, 14, and 21. Stepwise regression analyses using peak levels of the 25 cytokines and 15 clinical variables identified variables associated with bronchopulmonary dysplasia/death. Multivariate logistic regression analysis was performed for bronchopulmonary dysplasia/death by using variables selected through stepwise regression. Similar analyses were performed by using average cytokine values from days 0 to 21, days 0 to 3, and days 14 to 21.
RESULTS. Of 1062 infants with available data, 606 infants developed bronchopulmonary dysplasia or died. On the basis of results from all models combined, bronchopulmonary dysplasia/death was associated with higher concentrations of interleukin 1 beta, 6, 8, and 10 and interferon gamma and lower concentrations of interleukin 17, regulated on activation, normal T cell expressed and secreted, and tumor necrosis factor beta. Compared with models with only clinical variables, the addition of cytokine data improved predictive ability by a statistically significant but clinically modest magnitude.
CONCLUSIONS. The overall cytokine pattern suggests that bronchopulmonary dysplasia/death may be associated with impairment in the transition from the innate immune response mediated by neutrophils to the adaptive immune response mediated by T lymphocytes. Pediatrics 2009; 123: 1132-1141
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Details
- Title
- Cytokines Associated With Bronchopulmonary Dysplasia or Death in Extremely Low Birth Weight Infants
- Creators
- Namasivayam Ambalavanan - University of Alabama at BirminghamWaldemar A. Carlo - University of Alabama at BirminghamCarl T. D'Angio - University of RochesterScott A. McDonald - RTI InternationalAbhik Das - RTI InternationalDiana Schendel - National Center on Birth Defects and Developmental DisabilitiesPoul Thorsen - Emory UniversityRosemary D. Higgins - Office of Extramural ResearchEunice Kennedy Shriver Natl Inst C
- Publication Details
- Pediatrics (Evanston), v 123(4), pp 1132-1141
- Publisher
- Amer Acad Pediatrics
- Number of pages
- 10
- Grant note
- Department of Health and Human Services U10HD040498 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UG1HD027880 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Y1-HD-5000-01 / Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA M01 RR30; M01 RR32; M01 RR39; M01 RR44; M01 RR70; M01 RR80; M01 RR633; M01 RR750; M01 RR997; M01 RR6022; M01 RR7122; M01 RR8084; M01 RR16587 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1TR000454 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) M01RR008084 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R03 HD54420; U01 HD36790; U10 HD21364; U10 HD21373; U10 HD21385; U10 HD21397; U10 HD21415; U10 HD27851; U10 HD27853; U10 HD27856; U10 HD27871; U10 HD27880; U10 HD27881; U10 HD27904; U10 HD34216; U10 HD40461; U10 HD40492; U10 HD40498; U10 HD40521; U10 HD40689 / Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000264663100008
- Scopus ID
- 2-s2.0-65349120594
- Other Identifier
- 991021463673404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics