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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Cytokines and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
The Journal of pediatrics, v 159(6), pp 919-U77
01 Dec 2011
PMID: 21798559
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants.
Study design Infants with birth weights <= 1000 g (n = 1067) had blood samples collected at birth and on days 3 +/- 1, 7 +/- 1, 14 +/- 3, and 21 +/- 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1 beta; IL-8; tumor necrosis factor-a; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants.
Results IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-beta, soluble IL r alpha, macrophage inflammatory protein 1 beta) were found to be altered on days 0-4 in infants who developed CP.
Conclusions CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin. (J Pediatr 2011;159:919-25).
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Details
- Title
- Cytokines and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
- Creators
- Waldemar A. Carlo - University of Alabama at BirminghamScott A. McDonald - RTI InternationalJon E. Tyson - College Station Medical CenterBarbara J. Stoll - Emory UniversityRichard A. Ehrenkranz - Yale UniversitySeetha Shankaran - Wayne State UniversityRonald N. Goldberg - Duke UniversityAbhik Das - RTI InternationalDiana Schendel - National Center on Birth Defects and Developmental DisabilitiesPoul Thorsen - College Station Medical CenterKristin Skogstrand - Statens Serum InstitutDavid M. Hougaard - Statens Serum InstitutWilliam Oh - Women & Infants Hospital of Rhode IslandAbbot R. Laptook - The University of Texas Southwestern Medical CenterShahnaz Duara - University of MiamiAvroy A. Fanaroff - Rainbow Babies & Children's HospitalEdward F. Donovan - University of CincinnatiSheldon B. Korones - University of Tennessee Health Science CenterDavid K. Stevenson - Stanford UniversityLu-Ann Papile - University of New MexicoNeil N. Finer - University of California San DiegoT. Michael O'Shea - Wake Forest UniversityBrenda B. Poindexter - Indiana University – Purdue University IndianapolisLinda L. Wright - Eunice Kennedy Shriver CenterNamasivayam Ambalavanan - University of Alabama at BirminghamRosemary D. Higgins - Eunice Kennedy Shriver CenterEunice Kennedy Shriver Natl Inst C
- Publication Details
- The Journal of pediatrics, v 159(6), pp 919-U77
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA M01RR000044 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U10 HD21385; U10 HD40689; U10 HD27871; U10 HD21373; U01 HD36790; U10 HD40498; U10 HD40461; U10 HD34216; U10 HD21397; U10 HD27904; U10 HD40492; U10 HD27856; U10 HD40521; U10 HD27853; U10 HD27880; U10 HD27851; R03 HD054420 / Department of Health and Human Services GCRC M01 RR 08084; M01 RR 00125; M01 RR 00750; M01 RR 00070; M01 RR 0039-43; M01 RR 00039; 5 M01 RR00044 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1TR000454 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R03HD054420 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U10HD027856 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000296849400010
- Scopus ID
- 2-s2.0-80755128216
- Other Identifier
- 991021463445104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics