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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Cytokines and Posthemorrhagic Ventricular Dilation in Premature Infants
American journal of perinatology, v 29(9), pp 731-740
01 Oct 2012
PMID: 22773292
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To determine in extremely low-birth-weight infants if elevated blood interferon-gamma (IFN-gamma), interleukin (IL)-1 beta, IL-18, tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta are associated with need for shunt following severe intraventricular hemorrhage (IVH) or with ventricular dilation following milder grades/no IVH.
Study Design Whole blood cytokines were measured on postnatal days 1,3,7, 14, and 21. Maximum IVH grade in the first 28 days, and shunt surgery or ventricular dilation on subsequent ultrasound (28 days' to 36 weeks' postmenstrual age) were determined.
Results Of 902 infants in the National Institute of Child Health and Human Development Neonatal Research Network Cytokine study who survived to 36 weeks or discharge, 3.1% had shunts. Of the 12% of infants with severe (grade III to IV) IVH, 26% had a shunt associated with elevated TNF-alpha. None of the infants without IVH (69%) or with grade I(12%) or II (7%) IVH received shunts, but 8.4% developed ventricular dilation, associated with lower IFN-gamma and higher IL-18.
Conclusion Statistically significant but clinically nondiscriminatory alterations in blood cytokines were noted in infants with severe IVH who received shunts and in those without severe IVH who developed ventricular dilation. Blood cytokines are likely associated with brain injury but may not be clinically useful as biomarkers for white matter damage.
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Details
- Title
- Cytokines and Posthemorrhagic Ventricular Dilation in Premature Infants
- Creators
- Namasivayam Ambalavanan - University of Alabama at BirminghamWaldemar A. Carlo - University of Alabama at BirminghamScott A. McDonald - RTI InternationalAbhik Das - RTI InternationalDiana E. Schendel - Centers for Disease Control and PreventionPoul Thorsen - Lillebaelt HospitalDavid M. Hougaard - Statens Serum InstitutKristin Skogstrand - Statens Serum InstitutRosemary D. Higgins - Research Network (United States)Eunice Kennedy Shriver Natl Inst
- Publication Details
- American journal of perinatology, v 29(9), pp 731-740
- Publisher
- Thieme Medical Publishers
- Number of pages
- 10
- Grant note
- Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U10HD034216 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U10HD027881 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UL1TR000454 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA M01RR008084 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000308845900011
- Scopus ID
- 2-s2.0-84866555430
- Other Identifier
- 991021230006804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics