Journal article
Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants
Pediatric research, v 76(1), pp 100-108
01 Jul 2014
PMID: 24732104
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The goal was to identify cytokines associated with necrotizing enterocolitis (NEC). Based on our earlier reports of decreased tissue expression of transforming growth factor (TGF)-β, we hypothesized that infants with NEC also have low blood TGF-β levels. We further hypothesized that because fetal inflammation increases the risk of NEC, infants who develop NEC have elevated blood cytokine levels in early neonatal period.
Data on 104 extremely-low-birth-weight infants with NEC and 893 without NEC from 17 centers were analyzed. Clinical information was correlated with blood cytokine levels on postnatal day 1 (D1), D3, D7, D14, and D21.
Male gender, non-Caucasian/non-African American ethnicity, sepsis, lower blood TGF-β and interleukin (IL)-2 levels, and higher IL-8 levels were associated with NEC. The NEC group had lower TGF-β levels than controls since D1. The diagnosis of NEC was associated with elevated IL-1β, IL-6, IL-8, IL-10, monocyte chemoattractant protein-1/CC-motif ligand-2, macrophage inflammatory protein-1β/CC-motif ligand-3, and C-reactive protein.
Clinical characteristics, such as gender and ethnicity, and low blood TGF-β levels are associated with higher risk of NEC. Infants who developed NEC did not start with high blood levels of inflammatory cytokines, but these rose mainly after the onset of NEC.
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Details
- Title
- Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants
- Creators
- Akhil Maheshwari - University of Alabama at BirminghamRobert L Schelonka - University of Alabama at BirminghamReed A Dimmitt - University of Alabama at BirminghamWaldemar A Carlo - University of Alabama at BirminghamBreda Munoz-Hernandez - RTI InternationalAbhik Das - RTI InternationalScott A McDonald - RTI InternationalPoul Thorsen - University of Southern DenmarkKristin Skogstrand - Statens Serum InstitutDavid M Hougaard - Statens Serum InstitutRosemary D Higgins - National Institutes of HealthEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research NetworkDiana Elizabeth Schendel - A.J. Drexel Autism Institute
- Publication Details
- Pediatric research, v 76(1), pp 100-108
- Publisher
- Springer Nature
- Grant note
- U10 HD27856 / NICHD NIH HHS M01 RR997 / NCRR NIH HHS M01 RR16587 / NCRR NIH HHS U10 HD027871 / NICHD NIH HHS U10 HD27880 / NICHD NIH HHS M01 RR008084 / NCRR NIH HHS M01 RR016587 / NCRR NIH HHS UG1 HD027880 / NICHD NIH HHS U10 HD040498 / NICHD NIH HHS U10 HD27904 / NICHD NIH HHS U10 HD021373 / NICHD NIH HHS U10 HD040492 / NICHD NIH HHS M01 RR39 / NCRR NIH HHS M01 RR32 / NCRR NIH HHS R01HD059142 / NICHD NIH HHS M01 RR7122 / NCRR NIH HHS U10 HD27853 / NICHD NIH HHS U01 HD36790 / NICHD NIH HHS M01 RR70 / NCRR NIH HHS U10 HD040689 / NICHD NIH HHS R01 HD059142 / NICHD NIH HHS U10 HD027904 / NICHD NIH HHS M01 RR8084 / NCRR NIH HHS U10 HD40498 / NICHD NIH HHS Y1-HD-5000-01 / NICHD NIH HHS U10 HD40492 / NICHD NIH HHS M01 RR007122 / NCRR NIH HHS U10 HD021385 / NICHD NIH HHS UG1 HD034216 / NICHD NIH HHS U10 HD040461 / NICHD NIH HHS U10 HD053124 / NICHD NIH HHS M01 RR80 / NCRR NIH HHS U10 HD34216 / NICHD NIH HHS U10 HD27851 / NICHD NIH HHS M01 RR006022 / NCRR NIH HHS U10 HD21397 / NICHD NIH HHS U10 HD021397 / NICHD NIH HHS U10 HD21415 / NICHD NIH HHS U10 HD21364 / NICHD NIH HHS U10 HD027856 / NICHD NIH HHS U10 HD27871 / NICHD NIH HHS U10 HD027880 / NICHD NIH HHS U10 HD027853 / NICHD NIH HHS U10 HD021364 / NICHD NIH HHS U10 HD40689 / NICHD NIH HHS U10 HD027851 / NICHD NIH HHS U10 HD40461 / NICHD NIH HHS U10 HD21385 / NICHD NIH HHS M01 RR633 / NCRR NIH HHS M01 RR750 / NCRR NIH HHS U10 HD034216 / NICHD NIH HHS M01 RR6022 / NCRR NIH HHS U01 HD036790 / NICHD NIH HHS U10 HD21373 / NICHD NIH HHS U10 HD27881 / NICHD NIH HHS M01 RR30 / NCRR NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000337663900014
- Scopus ID
- 2-s2.0-84902651586
- Other Identifier
- 991021229889104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics