Journal article - Review
Cytokines in Allergic Conjunctivitis: Unraveling Their Pathophysiological Roles
Life (Basel, Switzerland), v 14(3), 350
01 Mar 2024
PMID: 38541674
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Allergic conjunctivitis is one of the common immune hypersensitivity disorders that affect the ocular system. The clinical manifestations of this condition exhibit variability contingent upon environmental factors, seasonal dynamics, and genetic predisposition. While our comprehension of the pathophysiological engagement of immune and nonimmune cells in the conjunctiva has progressed, the same cannot be asserted for the cytokines mediating this inflammatory cascade. In this review, we proffer a comprehensive description of interleukins 4 (IL-4), IL-5, IL-6, IL-9, IL-13, IL-25, IL-31, and IL-33, as well as thymic stromal lymphopoietin (TSLP), elucidating their pathophysiological roles in mediating the allergic immune responses on the ocular surface. Delving into the nuanced functions of these cytokines holds promise for the exploration of innovative therapeutic modalities aimed at managing allergic conjunctivitis.
Metrics
Details
- Title
- Cytokines in Allergic Conjunctivitis: Unraveling Their Pathophysiological Roles
- Creators
- DeGaulle I. Chigbu - Drexel University Elkins Park CampusNicholas J. Karbach - Drexel University Elkins Park CampusSampson L. Abu - Drexel University Elkins Park CampusNavpreet K. Hehar - Drexel University Elkins Park Campus
- Publication Details
- Life (Basel, Switzerland), v 14(3), 350
- Publisher
- MDPI
- Number of pages
- 29
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:001192807300001
- Scopus ID
- 2-s2.0-85193270779
- Other Identifier
- 991022019606904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biology
- Microbiology