Journal article
Cytomegalovirus-targeted immunotherapy and glioblastoma: hype or hope?
Immunotherapy, v 8(4), pp 413-423
01 Apr 2016
PMID: 26973123
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Malignant gliomas, including glioblastoma (GBM), are the most common primary brain tumors. Despite extensive research only modest gains have been made in long-term survival. Standard of care involves maximizing safe surgical resection followed by concurrent chemoradiation with temozolomide. Immunotherapy for GBM is an area of intense research in recent years. New immunotherapies, although promising, have not been integrated into standard practice. Human cytomegalovirus (HCMV) is a DNA virus of the family Herpesviridae. Human seroprevalence is approximately 80%, and in most cases, is associated with asymptomatic infection. HCMV may be an important agent in the initiation, promotion and/or progression of tumorigenesis. Regardless of a possible etiologic role in GBM, interest has centered on exploiting this association for development of immunomodulatory therapies.
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Details
- Title
- Cytomegalovirus-targeted immunotherapy and glioblastoma: hype or hope?
- Creators
- Sherise D. Ferguson - The University of Texas MD Anderson Cancer CenterVisish M. Srinivasan - Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, 1400 Holcombe Blvd,Unit 442, Houston, TX 77030 USAMichael G. Z. Ghali - Drexel UniversityAmy B. Heimberger - The University of Texas MD Anderson Cancer Center
- Publication Details
- Immunotherapy, v 8(4), pp 413-423
- Publisher
- Future Medicine Ltd
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000372262400005
- Scopus ID
- 2-s2.0-84962601965
- Other Identifier
- 991019312359104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology