Journal article
Cytoskeletal Reorganization during the Formation of Oligodendrocyte Processes and Branches
Molecular and cellular neurosciences, v 17(4), pp 624-636
Apr 2001
PMID: 11312599
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During oligodendrocyte development, signals relevant to process formation must be transduced into appropriate changes in cytoskeletal organization. We have explored how microtubules and microfilaments interact during the outgrowth and branching of oligodendrocyte processes in culture. We observed that microfilaments are enriched in the peripheral region beneath the plasma membrane and constitute the major cytoskeletal element at the leading edge of the process, which is also enriched in the B-isoform of the non-muscle myosin II heavy chain. Microtubules form a dense bundle within the process and splay before extending into the leading edge and branches, following tracks laid by microfilaments. Pharmacologic disruption of microfilaments and microtubules compromised normal process outgrowth and branching. However, microtubules rapidly reinvaded most processes after removal of both antimicrotubule and antimicrofilament drugs, but the reinvasion was severely compromised if the antimicrofilament drug was retained. These results are consistent with the hypothesis that microfilaments guide the local reorganization of microtubules for the elongation of oligodendrocyte processes and the formation of new branches.
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Details
- Title
- Cytoskeletal Reorganization during the Formation of Oligodendrocyte Processes and Branches
- Creators
- Jonathan Song - Department of Medical Science, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, 53706Brian D Goetz - Department of Medical Science, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, 53706Peter W Baas - Department of Neurobiology and Anatomy, MCP Hahnemann University, Philadelphia, Pennsylvania, 19129Ian D Duncan - Department of Medical Science, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, 53706
- Publication Details
- Molecular and cellular neurosciences, v 17(4), pp 624-636
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000168480800002
- Scopus ID
- 2-s2.0-0035012459
- Other Identifier
- 991014877773704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences