Journal article
Cytotoxicity tests of water soluble ZnS and CdS quantum dots
Journal of nanoscience and nanotechnology, v 11(4), pp 3543-3551
Apr 2011
PMID: 21776735
Abstract
Cytotoxicity tests of zinc sulfide (ZnS) and cadmium sulfide (CdS) quantum dots (QDs) synthesized via all-aqueous process with various surface conditions were carried out with human endothelial cells (EA hy926) using two independent viability assays, i.e., by cell counting following Trypan blue staining and by measuring Alamar Blue (AB) fluorescence. The ZnS QDs with all four distinct types of surface conditions were nontoxic at both 1 microM and 10 microM concentrations for at least 6 days. On the other hand, the CdS QDs were nontoxic only at 1 microM, and showed significant cytotoxicity at 10 microM after 3 days in the cell counting assay and after 4 days in the AB fluorescence assay. The CdS QDs with (3-mercaptopropyl)trimethoxysilane (MPS)-replacement plus silica capping were less cytotoxic than those with 3-mercaptopropionic acid (MPA) capping and those with MPS-replacement capping. Comparing the results of ZnS and CdS QDs with the same particle size, surface condition and concentration, it is indicated that the cytotoxicity of CdS QDs and the lack of it in ZnS QDs were probably due to the presence and absence of the toxic Cd element, respectively. The nontoxicity of the aqueous ZnS QDs makes them favorable for in vivo imaging applications.
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Details
- Title
- Cytotoxicity tests of water soluble ZnS and CdS quantum dots
- Creators
- Hui Li - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USAMengyan LiWan Y ShihPeter I LelkesWei-Heng Shih
- Publication Details
- Journal of nanoscience and nanotechnology, v 11(4), pp 3543-3551
- Publisher
- United States
- Grant note
- 1 R01 EB000720 / NIBIB NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Materials Science and Engineering
- Web of Science ID
- WOS:000289176100106
- Scopus ID
- 2-s2.0-80051930096
- Other Identifier
- 991014877954304721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Multidisciplinary
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter