Journal article
D-2 dopamine receptor antisense increases the activity and mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in mouse brain
Neuroscience letters, v 217(2-3), pp 105-108
18 Oct 1996
PMID: 8916083
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A D-2 dopamine receptor antisense oligodeoxynucleotide was administered intracerebrovetricularly to mice twice on the first day and then once daily for 2 days. The animals were killed 2 h after the last injection, and tyrosine hydroxylase and aromatic L-amino acid decarboxylase activities assayed in the corpus striatum, olfactory tubercle and frontal cortex. Tyrosine hydroxylase activity increased in corpus striatum but not in the olfactory tubercle or in the frontal cortex, while the activity of aromatic L-amino acid decarboxylase increased in all three brain regions. The treatment with the antisense oligomer also elevated the mRNA levels for the two enzymes in the midbrain. In contrast, repeated injection of a vehicle or a random oligomer was without effect on enzyme activity or mRNA D-2 antisense oligodeoxynucleotides appear to be selective tools to investigate the role of D-2 dopamine receptors in brain.
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Details
- Title
- D-2 dopamine receptor antisense increases the activity and mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in mouse brain
- Creators
- M HadjiconstantinouN H NeffL W ZhouB Weiss
- Publication Details
- Neuroscience letters, v 217(2-3), pp 105-108
- Publisher
- Elsevier
- Number of pages
- 4
- Grant note
- MH42148 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) NS34571 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R37MH042148 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01NS034571 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1996VQ39800009
- Scopus ID
- 2-s2.0-0030592329
- Other Identifier
- 991019168677404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences