Journal article
[D-P [formula omitted]n 5]enkephalin induced analgesia in the jimpy mouse: in vivo evidence for δ-receptor mediated analgesia
European journal of pharmacology, v 136(3), pp 405-407
1987
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Abstract
Jimpy (B6CBA-A W-J/A-Ta jp) mice, which are known to be deficient in neuronal cerebroside sulfate (a putative component of the μ opioid receptor), were non-responsive in the tail flick test (compared to littermate controls and a standard Swiss strain of mouse) to analgesic doses of two μ opioid receptor agonists, morphine sulfate and [D-Ala
2,MePhe
4,Gly-ol
5]enkephalin (DAGO). However, the jimpy mice responded normally (compared to controls) to the analgesic effects of the selective δ opioid receptor agonist [D-P
en
2,L-Pe
n
5]enkephalin (DPLPE). These results suggest (1) that δ opioid receptors can mediate analgesia and (2) that cerebroside sulfate is not necessary for δ opioid receptor activation.
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Details
- Title
- [D-P [formula omitted]n 5]enkephalin induced analgesia in the jimpy mouse: in vivo evidence for δ-receptor mediated analgesia
- Creators
- Joanne R. Mathiasen - SpringhouseJeffry L. Vaught - Springhouse
- Publication Details
- European journal of pharmacology, v 136(3), pp 405-407
- Publisher
- Elsevier; AMSTERDAM
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1987H605000017
- Scopus ID
- 2-s2.0-0023160010
- Other Identifier
- 991021900019204721
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- Web of Science research areas
- Pharmacology & Pharmacy