Journal article
(D-Pen super(2),L-Pen super(5))enkephalin induced analgesia in the jimpy mouse: In vivo evidence for delta -receptor mediated analgesia
European journal of pharmacology, Vol.136(3), pp.405-407
01 Jan 1987
Abstract
Jimpy (B6CBA-A W-J/A-Ta jp) mice, which are known to be deficient in neuronal cerebroside sulfate (a putative component of the mu opioid receptor), were non-responsive in the tail flick test to analgesic doses of two mu opioid receptor agonists. However, the jimpy mice responded normally to the analgesic effects of a selective delta opioid receptor agonist. The results suggest that delta opioid receptors can mediate analgesia and that cerebroside sulfate is not necessary for delta opioid receptor activation.
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Details
- Title
- (D-Pen super(2),L-Pen super(5))enkephalin induced analgesia in the jimpy mouse: In vivo evidence for delta -receptor mediated analgesia
- Creators
- J MathiasenJ Vaught
- Publication Details
- European journal of pharmacology, Vol.136(3), pp.405-407
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Identifiers
- 991021900194104721