Logo image
Back
D sub(1)-Like Dopamine Receptor-Mediated Function in Congenic Mutants with D sub(1) vs. D sub(5) Receptor "Knockout"
Journal article   Peer reviewed

D sub(1)-Like Dopamine Receptor-Mediated Function in Congenic Mutants with D sub(1) vs. D sub(5) Receptor "Knockout"

G O'Sullivan, J Clifford, K Tomiyama, N Koshikawa, J Drago, D R Sibley, D Croke and J Waddington
Journal of receptors and signal transduction, v 24(3), pp 107-116
01 Jan 2004
DOI: https://doi.org/10.1081/LRST-200032078
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Current understanding of the functional roles of individual dopamine D sub(1)-like [D sub(1), D sub(5)] and D sub(2)-like [D sub(2L/S), D sub(3), D sub(4)] receptor subtypes remains incomplete. In particular, the lack of pharmacological agonists and antagonists able to distinguish between D sub(1) and D sub(5) receptors means that any differential roles in the regulation of behavior are poorly understood. Mutant mice with targeted gene deletion ("knockout") of individual dopamine receptor subtypes offer an important alternative approach to resolving these functional roles. In cogenic D sub(1) mutants examined ethologically, progressive increases in specific topographies of behavior over wildtypes were considerably greater than those in D sub(1) mutants on a mixed genetic background; D sub(1) knockout appears to influence the neuronal substrate(s) of habituation to disrupt sculpture of the changing topography of behavior from initial exploration through to quiescence. Similarly, the D sub(1) receptor appears to regulate specific topographies of orofacial movement in the mouse as these are "sculpted" in a time-dependent manner. Although the well-recognized role of the D sub(1)-like family in regulating several aspects of behavioral topography has been assumed to involve primarily D sub(1) receptors, this presumption may require modification to accommodate a subtle but not negligible role for their D sub(5) counterparts as evidenced in the phenotype of congenic D sub(5) mutants.

Metrics

5 Record Views
9 citations in Web of Science

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Biochemistry & Molecular Biology
Cell Biology
Logo image