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Journal article
D3, the new diffractometer for the macromolecular crystallography beamlines of the Swiss Light Source
Journal of synchrotron radiation, v 21(Pt 2), pp 340-351
04 Feb 2014
PMID: 24562555
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A new diffractometer for microcrystallography has been developed for the three macromolecular crystallography beamlines of the Swiss Light Source.
A new diffractometer for microcrystallography has been developed for the three macromolecular crystallography beamlines of the Swiss Light Source. Building upon and critically extending previous developments realised for the high-resolution endstations of the two undulator beamlines X06SA and X10SA, as well as the super-bend dipole beamline X06DA, the new diffractometer was designed to the following core design goals. (i) Redesign of the goniometer to a sub-micrometer peak-to-peak cylinder of confusion for the horizontal single axis. Crystal sizes down to at least 5 µm and advanced sample-rastering and scanning modes are supported. In addition, it can accommodate the new multi-axis goniometer PRIGo (Parallel Robotics Inspired Goniometer). (ii) A rapid-change beam-shaping element system with aperture sizes down to a minimum of 10 µm for microcrystallography measurements. (iii) Integration of the on-axis microspectrophotometer MS3 for microscopic sample imaging with 1 µm image resolution. Its multi-mode optical spectroscopy module is always online and supports
in situ
UV/Vis absorption, fluorescence and Raman spectroscopy. (iv) High stability of the sample environment by a mineral cast support construction and by close containment of the cryo-stream. Further features are the support for
in situ
crystallization plate screening and a minimal achievable detector distance of 120 mm for the Pilatus 6M, 2M and the macromolecular crystallography group’s planned future area detector Eiger 16M.
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Details
- Title
- D3, the new diffractometer for the macromolecular crystallography beamlines of the Swiss Light Source
- Creators
- Martin R. Fuchs - Brookhaven National LaboratoryClaude Pradervand - Paul Scherrer InstituteVincent Thominet - Paul Scherrer InstituteRoman Schneider - Paul Scherrer InstituteEzequiel Panepucci - Paul Scherrer InstituteMarcel Grunder - Paul Scherrer InstituteJose Gabadinho - Paul Scherrer InstituteFlorian S. N. Dworkowski - Paul Scherrer InstituteTakashi Tomizaki - Paul Scherrer InstituteJörg Schneider - Paul Scherrer InstituteAline Mayer - Paul Scherrer InstituteAdrian Curtin - Paul Scherrer InstituteVincent Olieric - Paul Scherrer InstituteUli Frommherz - Paul Scherrer InstituteGoran Kotrle - Paul Scherrer InstituteJörg Welte - Paul Scherrer InstituteXinyu Wang - Paul Scherrer InstituteStephan Maag - Paul Scherrer InstituteClemens Schulze-Briese - Tris PharmaMeitian Wang - Paul Scherrer InstituteBrookhaven National Laboratory (BNL)
- Publication Details
- Journal of synchrotron radiation, v 21(Pt 2), pp 340-351
- Publisher
- International Union of Crystallography
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000331836900006
- Scopus ID
- 2-s2.0-84894455990
- Other Identifier
- 991019176800104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Instruments & Instrumentation
- Optics
- Physics, Applied