Journal article
DC-SIGN facilitates productive infection of monocyte-derived dendritic cells by human T cell leukemia virus type 1
Journal of neurovirology, Vol.12, pp.35-35
01 May 2006
Abstract
Human T cell leukemia virus type 1 (HTLV-1) has been identified as the etiologic agent of adult T cell leukemia (ATL) and the neurologic disorder, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Numerous studies of HAM/TSP patients have demonstrated the generation of an intense cytotoxic T cell (CTL) response with large numbers of CD8+ CTLs directed against the HTLV-1 oncoprotein Tax 11-19 peptide. Additional studies have demonstrated that patients diagnosed with HAM/TSP exhibit rapid activation and maturation of dendritic cells (DCs) while ATL patients exhibit a maturation defect in this cell lineage. In addition to T cells, HTLV-1 is known to infect DCs. HTLV-1 infection of DCs could alter general DC function or the specific processing and/or presentation of HTLV-1-specific peptides, potentially playing a major role in the course of HTLV-1-associated disease. In this regard, we have demonstrated that an important antigen receptor on DCs, DC-SIGN (dendritic cell-specific ICAM-3 grabbing non-integrin), a C-type lectin, serves as a receptor for HTLV-1 binding using a quantum dot-based fluorescent binding assay. We have also demonstrated that silencing of DC-SIGN inhibits the infection of DC in a DC/T cell co-infection system. Furthermore, expression of DC-SIGN in B cells enhances viral binding, entry and infection. These investigations, which consider the involvement of DC surface molecules in HTLV-1 pathogenesis, are among the first explorations of the intricate mechanisms that underlie the interactions of HTLV-1 with the DC compartment. Our results provide further insights into the participation of DCs in HTLV-1 pathogenesis and increase our understanding of adhesion pathways that regulate DC trafficking and interactions with T cells during the development of disease.
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Details
- Title
- DC-SIGN facilitates productive infection of monocyte-derived dendritic cells by human T cell leukemia virus type 1
- Creators
- P JainJ AhujaK KampaniK FlaigB Wigdahl
- Publication Details
- Journal of neurovirology, Vol.12, pp.35-35
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991019170560904721