DNA Damage Detection by 53BP1: Relationship to Species Longevity

Eleonora Croco; Silvia Marchionni; Martine Bocchini; Cristina Angeloni; Thomas Stamato; Claudio Stefanelli; Silvana Hrelia; Christian Sell; Antonello Lorenzini

doi:10.1093/gerona/glw170

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DNA Damage Detection by 53BP1: Relationship to Species Longevity

Journal article

Open access

Peer reviewed

DNA Damage Detection by 53BP1: Relationship to Species Longevity

Eleonora Croco, Silvia Marchionni, Martine Bocchini, Cristina Angeloni, Thomas Stamato, Claudio Stefanelli, Silvana Hrelia, Christian Sell and Antonello Lorenzini

The journals of gerontology. Series A, Biological sciences and medical sciences, v 72(6), pp 763-770

01 Jun 2017

DOI: https://doi.org/10.1093/gerona/glw170

PMID: 27573809

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Animals

Cattle

Cell Cycle Checkpoints

Cell Line

Chiroptera

Cyclin A - metabolism

Cytotoxins - toxicity

DNA Damage

DNA Fragmentation

Dogs

Etoposide - toxicity

Fibroblasts - drug effects

Fibroblasts - metabolism

Genomic Instability

Histones - metabolism

Humans

Life Expectancy

Longevity

Mice

Micronuclei, Chromosome-Defective

Micronucleus Tests

NIMA-Related Kinases - metabolism

Topoisomerase II Inhibitors - toxicity

Tumor Suppressor p53-Binding Protein 1 - metabolism

Zinostatin - toxicity

In order to examine potential differences in genomic stability, we have challenged fibroblasts derived from five different mammalian species of variable longevity with the genotoxic agents, etoposide and neocarzinostatin. We report that cells from longer-lived species exhibit more tumor protein p53 binding protein 1 (53BP1) foci for a given degree of DNA damage relative to shorter-lived species. The presence of a greater number of 53BP1 foci was associated with decreased DNA fragmentation and a lower percentage of cells exhibiting micronuclei. These data suggest that cells from longer-lived species have an enhanced DNA damage response. We propose that the number of 53BP1 foci that form in response to damage reflects the intrinsic capacity of cells to detect and respond to DNA harms.

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27 citations in Scopus

Details

Title: DNA Damage Detection by 53BP1: Relationship to Species Longevity
Creators: Eleonora Croco - Department for Life Quality Studies and
Silvia Marchionni - University of Bologna
Martine Bocchini - University of Bologna
Cristina Angeloni - Department for Life Quality Studies and
Thomas Stamato - Lankenau Institute for Medical Research
Claudio Stefanelli - Department for Life Quality Studies and
Silvana Hrelia - Department for Life Quality Studies and
Christian Sell - Drexel University
Antonello Lorenzini - University of Bologna
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, v 72(6), pp 763-770
Publisher: Oxford University Press
Resource Type: Journal article
Language: English
Academic Unit: Biochemistry and Molecular Biology
Web of Science ID: WOS:000404877800006
Scopus ID: 2-s2.0-85019416280
Other Identifier: 991019169627404721

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Collaboration types: Domestic collaboration; International collaboration
Web of Science research areas: Geriatrics & Gerontology; Gerontology

DNA Damage Detection by 53BP1: Relationship to Species Longevity

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Abstract

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Details

UN Sustainable Development Goals (SDGs)

InCites Highlights

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