Journal article
DNA Methylation Is Associated With Eating Behavior- Related Factors Among Adults With Obesity
Obesity (Silver Spring, Md.), Vol.30, pp.236-236
01 Nov 2022
Abstract
Background: The role of the epigenome on eating behavior-related factors in the context of obesity remains poorly understood. Our goal was to examine the association between DNA methylation (DNAme) and eating behavior in adults with overweight/obesity (OW/OB). Methods: Whole blood DNA methylation (DNAme) was measured via the Illumina EPIC 850K array in 62 adults with OW/OB (age 41±10 y; 89% White; 24% Male, BMI 33±4 kg/m2), and adjusted for cell-composition. Concurrent measures of eating behavior included energy intake (EI, doubly labeled water), delay discounting, motivation to consume palatable foods to cope with a negative state, diet self-efficacy (WEL-SF), reward-based eating (RED), and disinhibition/hunger/cognitive restraint (TFEQ-r18). Linear regression was used to examine the association between DNAme and eating behaviors using a false discovery rate (FDR)<0.10 to account for multiple testing. For analyses where >100 CpGs passed FDR, gene set overrepresentation analyses were performed via Enrichr. Results: We identified 139 CpGs annotating to 160 genes associated with EI (kcal/d); Genes were enriched in 41 biological pathways (p <0.05). Top hits included: inflammation mediated by chemokine and cytokine signaling pathway and transcriptional activity of SMAD3. 39 CpGs were associated with delay discounting; 11 CpGs annotated to biologically relevant genes associated with obesity, reward-related brain regions, impulsivity, addictive behaviors, and/or opioid addiction including: HTR3A, SORCS2, and GRIN3A, among others. 2 CpGs were associated with motivation to eat palatable foods, 2 CpGs with diet self-efficacy, and no CpGs were associated with reward-based eating, disinhibition, hunger, or cognitive restraint. Conclusions: Valuing immediate over late rewards is linked to several CpGs that annotate onto genes associated with obesity and addictivelike behaviors. Preliminary results suggest that adults with OW/OB may have altered expression of reward-related gene pathways, impacting unhealthy eating behaviors.
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Details
- Title
- DNA Methylation Is Associated With Eating Behavior- Related Factors Among Adults With Obesity
- Creators
- Lindsay ShoganSarah BorengasserEmily CooperCuining LiuKatherina Kechris-MaysErica LafataJasper HeinsbroekMaggie StanislawskiAnnie CaldwellSeth CreasyDanielle OstendorfEdward MelansonVictoria Catenacci
- Publication Details
- Obesity (Silver Spring, Md.), Vol.30, pp.236-236
- Publisher
- Blackwell Publishing Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- WELL Center
- Identifiers
- 991020836467804721