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Journal article
DNA markers in molecular diagnostics for hepatocellular carcinoma
Expert review of molecular diagnostics, v 14(7), pp 803-817
01 Sep 2014
PMID: 25098554
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hepatocellular carcinoma (HCC) is the one of the leading causes of cancer mortality in the world, mainly due to the difficulty of early detection and limited therapeutic options. The implementation of HCC surveillance programs in well-defined, high-risk populations were only able to detect about 40-50% of HCC at curative stages (Barcelona Clinic Liver Cancer stages 0 & 1) due to the low sensitivities of the current screening methods. The advance of sequencing technologies has identified numerous modifications as potential candidate DNA markers for diagnosis/surveillance. Here we aim to provide an overview of the DNA alterations that result in activation of cancer pathways known to potentially drive HCC carcinogenesis and to summarize performance characteristics of each DNA marker in the periphery (blood or urine) for HCC screening.
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Details
- Title
- DNA markers in molecular diagnostics for hepatocellular carcinoma
- Creators
- Ying-Hsiu Su - Drexel UniversitySelena Y. Lin - Drexel UniversityWei Song - JBS Science (United States)Surbhi Jain - JBS Science
- Publication Details
- Expert review of molecular diagnostics, v 14(7), pp 803-817
- Publisher
- Taylor & Francis
- Number of pages
- 15
- Grant note
- R43 CA165312; R44 CA165312 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R43CA165312 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000340829200004
- Scopus ID
- 2-s2.0-84906317471
- Other Identifier
- 991019167645204721
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- Web of Science research areas
- Pathology