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Daptomycin (LY146032) treatment of experimental enterococcal endocarditis
Journal article   Open access   Peer reviewed

Daptomycin (LY146032) treatment of experimental enterococcal endocarditis

L M Bush, J A Boscia and D Kaye
Antimicrobial agents and chemotherapy, v 32(6), pp 877-881
Jun 1988
DOI: https://doi.org/10.1128/AAC.32.6.877
PMID: 2843085
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1128/aac.32.6.877View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Animals Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Daptomycin Endocarditis, Bacterial - drug therapy Endocarditis, Bacterial - microbiology Enterococcus faecalis Female Half-Life Microbial Sensitivity Tests Peptides - pharmacokinetics Peptides - therapeutic use Rabbits Streptococcal Infections - drug therapy Streptococcal Infections - microbiology
This study compared daptomycin (LY146032) with penicillin G procaine and vancomycin without and with gentamicin for treatment of experimental enterococcal endocarditis. The strain of Streptococcus (Enterococcus) faecalis used in this study was killed by daptomycin in vitro in broth but not in serum. In rabbits treated for 3 days, daptomycin significantly reduced bacterial counts of vegetations compared with no therapy but was significantly less effective than penicillin G procaine or vancomycin. Daptomycin-gentamicin significantly reduced bacterial counts of vegetations compared with daptomycin alone but was significantly less effective than vancomycin plus gentamicin. The efficacy of daptomycin-gentamicin did not differ significantly from that of penicillin G procaine-gentamicin. The lack of enterococcal killing by daptomycin alone in serum and in experimental endocarditis is probably related to the high protein binding of the agent.

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Web of Science research areas
Microbiology
Pharmacology & Pharmacy
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