Journal article
Data Processing and Analytic Support in the PLCO Cancer Screening Trial
Reviews on recent clinical trials, v 10(3)
01 Jan 2015
PMID: 26238116
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial was a large, randomized controlled trial of cancer screening that also evolved over time into a unique epidemiologic cohort. Vast quantities of data have been collected since the beginning of the trial in 1993. Screening data was obtained through 2006. Questionnaire-based risk factor data (collected at baseline and at other points in the trial), vital status, cancer diagnoses and treatment, biospecimen data and additional ancillary efforts continue to be collected.
Accurate data collection and efficient management methods are required to ensure high-quality data and valid and consistent analyses of trial outcomes. Information Management Services (IMS) was and continues to be responsible for processing and converting the collected raw PLCO data into comprehensive and accessible datasets. IMS also continues to provide a wide spectrum of analytic support including support for trial monitoring, data sharing, and epidemiologic research. In this paper, we describe the data processing and management requirements from the analytic team perspective, highlighting the various data sources and their complexity. We also illustrate the construction of usable analytic data files and discuss the wide range of analytic support provided. Instructions for accessing PLCO data also are provided.
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Details
- Title
- Data Processing and Analytic Support in the PLCO Cancer Screening Trial
- Creators
- Jerome Mabie - Information Management ServicesTom Riley - Informat Management Serv Inc, 6110 Executive Blvd,Suite 310, Rockville, MD 20852 USAPamela M. Marcus - NCI, NIH, Div Canc Control & Populat Sci, Rockville, MD USAAmanda Black - NCI, NIH, Div Canc Epidemiol & Genet, Rockville, MD USAHeather Rozjabek - Drexel Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USAKelly Yu - NCI, NIH, Div Canc Prevent, Rockville, MD USAMichael Young - Informat Management Serv Inc, 6110 Executive Blvd,Suite 310, Rockville, MD 20852 USAJoe Austin - Informat Management Serv Inc, 6110 Executive Blvd,Suite 310, Rockville, MD 20852 USAJosh Rathmell - Informat Management Serv Inc, 6110 Executive Blvd,Suite 310, Rockville, MD 20852 USACraig Williams - Informat Management Serv Inc, 6110 Executive Blvd,Suite 310, Rockville, MD 20852 USAPhilip C. Prorok - NCI, NIH, Div Canc Prevent, Rockville, MD USAChihiro Williams - Global Studies and Modern Languages
- Publication Details
- Reviews on recent clinical trials, v 10(3)
- Publisher
- Bentham Science Publ Ltd
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Global Studies and Modern Languages
- Web of Science ID
- WOS:000420040900010
- Scopus ID
- 2-s2.0-84946031674
- Other Identifier
- 991019173528704721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy