Journal article
Deceased-donor acute kidney injury is not associated with kidney allograft failure
Kidney international, v 95(1)
Jan 2019
PMID: 30470437
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Deceased-donor acute kidney injury (AKI) is associated with organ discard and delayed graft function, but data on longer-term allograft survival are limited. We performed a multicenter study to determine associations between donor AKI (from none to severe based on AKI Network stages) and all-cause graft failure, adjusting for donor, transplant, and recipient factors. We examined whether any of the following factors modified the relationship between donor AKI and graft survival: kidney donor profile index, cold ischemia time, donation after cardiac death, expanded-criteria donation, kidney machine perfusion, donor-recipient gender combinations, or delayed graft function. We also evaluated the association between donor AKI and a 3-year composite outcome of all-cause graft failure or estimated glomerular filtration rate ≤ 20 mL/min/1.73 m2 in a subcohort of 30% of recipients. Among 2,430 kidneys transplanted from 1,298 deceased donors, 585 (24%) were from donors with AKI. Over a median follow-up of 4.0 years, there were no significant differences in graft survival by donor AKI stage. We found no evidence that pre-specified variables modified the effect of donor AKI on graft survival. In the subcohort, donor AKI was not associated with the 3-year composite outcome. Donor AKI was not associated with graft failure in this well-phenotyped cohort. Given the organ shortage, the transplant community should consider measures to increase utilization of kidneys from deceased donors with AKI.
[Display omitted]
Metrics
Details
- Title
- Deceased-donor acute kidney injury is not associated with kidney allograft failure
- Creators
- Isaac E. Hall - University of UtahEnver Akalin - Albert Einstein College of MedicineJonathan S. Bromberg - University of Maryland, BaltimoreMona D. Doshi - University of MichiganTom Greene - University of UtahMeera N. Harhay - Drexel UniversityYaqi Jia - Johns Hopkins MedicineSherry G. Mansour - Yale UniversitySumit Mohan - Columbia UniversityThangamani Muthukumar - Presbyterian HospitalPeter P. Reese - University of PennsylvaniaBernd Schröppel - University Hospital UlmPooja Singh - Thomas Jefferson University HospitalHeather R. Thiessen-Philbrook - Johns Hopkins MedicineFrancis L. Weng - Saint Barnabas Medical CenterChirag R. Parikh - Johns Hopkins Medicine
- Publication Details
- Kidney international, v 95(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000454622100025
- Scopus ID
- 2-s2.0-85059501587
- Other Identifier
- 991019335325204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Urology & Nephrology