Journal article
Deceleration of age-specific mortality rates in chromosomal homozygotes and heterozygotes of Drosophila melanogaster
Experimental gerontology, v 31(4), pp 517-531
1996
PMID: 9415108
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Age-specific mortality trajectories were estimated in mixed-sex cohorts of
D. melanogaster. We studied 22,000 flies that were either second-chromosome homozygotes or heterozygotes with a randomized genetic background. Broad-sense heritabilities for longevity were estimated to be 6% for males and 9% for females. Heterozygotes lived longer than homozygotes on average, but there were exceptions to the usual heterotic pattern; in several crosses parental homozygotes had average life spans as long as that of their F
1 heterozygotes. Estimated age-specific mortality rates were found to decelerate at advanced ages in both homozygotes and heterozygotes. The mortality models that best fit the data are the logistic model and the two-stage Gompertz model, both of which produce mortality trajectories that level off at advanced ages. Old-age mortality deceleration is not peculiar to inbred
Drosophila.
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Details
- Title
- Deceleration of age-specific mortality rates in chromosomal homozygotes and heterozygotes of Drosophila melanogaster
- Creators
- H.Henry FukuiLloyd AckertJames W Curtsinger
- Publication Details
- Experimental gerontology, v 31(4), pp 517-531
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- History
- Web of Science ID
- WOS:A1996UV63400008
- Scopus ID
- 2-s2.0-0030201078
- Other Identifier
- 991014878349504721
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- Web of Science research areas
- Geriatrics & Gerontology