Journal article
Decerebrate mammalian preparations: unalleviated or fully alleviated pain? A review and opinion
Contemporary topics in laboratory animal science, v 44(4), pp 34-36
Jul 2005
PMID: 16050666
Abstract
In experimental decerebration of mammals, the cerebral cortex and thalamus are surgically or otherwise inactivated under traditional (pharmacologic) general anesthesia. Once the effects of the pharmacologic anesthesia have dissipated, the animal remains alive, but there is neither pain sensation nor consciousness. Because the Animal Welfare Act and its regulations recognize drugs as the only means to alleviate pain, it is unclear whether a decerebrate animal should be placed in U.S. Department of Agriculture (USDA) pain and distress category D (pain or distress alleviated by drugs) or E (unalleviated pain or distress). We present a rationale for including decerebrate animals in USDA category D. We also provide a general review of decerebration and suggestions for institutional animal care and use committees having to evaluate decerebration protocols.
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Details
- Title
- Decerebrate mammalian preparations: unalleviated or fully alleviated pain? A review and opinion
- Creators
- Jerald Silverman - Department of Animal Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USANelson L GarnettSimon F GiszterCharles J Heckman, 2ndJodie A Kulpa-EddyMichel A LemayConstance K PerryMartin Pinter
- Publication Details
- Contemporary topics in laboratory animal science, v 44(4), pp 34-36
- Publisher
- United States
- Grant note
- P50 NS024707 / NINDS NIH HHS P50 NS024707-160011 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Health Administration
- Web of Science ID
- WOS:000230764900007
- Scopus ID
- 2-s2.0-22844434584
- Other Identifier
- 991014878616804721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Veterinary Sciences
- Zoology