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Published, Version of Record (VoR)Open Access Discount via Drexel Libraries Read and Publish Program 2026CC BY V4.0, Open
Journal article
Decoding the lncRNA world: comprehensive approaches to lncRNA structure and interactome studies
Cells, v 15(2), 105
06 Jan 2026
PMID: 41597180
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Recent advances in sequencing technologies have highlighted long non-coding RNAs (lncRNAs) as key regulators that perform essential biological functions without encoding proteins. Despite growing interest, the molecular mechanisms of most lncRNAs remain poorly understood, with only a few characterized in detail. A promising strategy to elucidate these mechanisms is to explore their structure–function relationships. Such studies require advanced biophysical and biochemical methods due to the large size and structural complexity of lncRNAs. Equally important is the analysis of lncRNA interactomes, which reveal how lncRNAs engage RNA-binding proteins and other biomolecules to drive conformational and functional changes underlying diverse biological pathways. Ultimately, integrative approaches combining structural and interactome analyses will yield deeper insight into lncRNA function and uncover new therapeutic opportunities. This review highlights recent advances in elucidating lncRNA structure–function relationships by integrating biophysical, biochemical, and sequencing-based approaches to overcome challenges of size and heterogeneity, identify functional binding partners, and inform therapeutic target development.
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Details
- Title
- Decoding the lncRNA world: comprehensive approaches to lncRNA structure and interactome studies
- Creators
- Srinivas Somarowthu (Corresponding Author) - Drexel University, Biochemistry and Molecular Biology
- Publication Details
- Cells, v 15(2), 105
- Publisher
- MDPI
- Number of pages
- 30
- Grant note
- Work in the Somarowthu Lab is partially supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R01GM149780 and by the Pennsylvania Department of Health CURE Grant [SAP #4100095603].
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:001670200400001
- Scopus ID
- 2-s2.0-105028841889
- Other Identifier
- 991022148305904721
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- Web of Science research areas
- Cell Biology