Journal article
Decoding the rules of recruitment of excitatory interneurons in the adult zebrafish locomotor network
Proceedings of the National Academy of Sciences - PNAS, v 109(52), pp E3631-E3639
26 Dec 2012
PMID: 23236181
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neural networks in the spinal cord transform signals from the brain into coordinated locomotor movements. An optimal adjustment of the speed of locomotion entails a precise order of recruitment of interneurons underlying excitation within these networks. However, the mechanisms encoding the recruitment threshold of excitatory interneurons have remained unclear. Here we show, using a juvenile/adult zebrafish preparation, that excitatory V2a interneurons are incrementally recruited with increased swimming frequency. The order of recruitment is not imprinted by the topography or the input resistance of the V2a interneurons. Rather, it is determined by scaling the effect of excitatory synaptic currents by the input resistance. We also show that the locomotor networks are composed of multiple microcircuits encompassing subsets of V2a interneurons and motoneurons that are recruited in a continuum with increased swimming speeds. Thus, our results provide insights into the organization and mechanisms determining the recruitment of spinal microcircuits to ensure optimal execution of locomotor movements.
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Details
- Title
- Decoding the rules of recruitment of excitatory interneurons in the adult zebrafish locomotor network
- Creators
- Jessica Ausborn - Karolinska InstitutetRiyadh Mahmood - Karolinska InstitutetAbdeljabbar El Manira - Karolinska Institutet
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 109(52), pp E3631-E3639
- Publisher
- Natl Acad Sciences
- Number of pages
- 9
- Grant note
- European Commission (FP7, Spinal Cord Repair); European Commission AU 329/2-1 / German Research Foundation; German Research Foundation (DFG) Karolinska Institute; Karolinska Institutet Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000313627700007
- Scopus ID
- 2-s2.0-84871837446
- Other Identifier
- 991020655545004721
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- Web of Science research areas
- Neurosciences