Journal article
Decreased IL-2, IFN-γ, and IL-10 Production by Aged Mice During the Acute Phase of E55+ Retrovirus Infection
Virology (New York, N.Y.), v 299(1)
2002
PMID: 12167336
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We previously reported that aged mice demonstrated a 12-week delay in virus clearance compared to young mice after infection with E55+ murine leukemia retrovirus (E55+MuLV). The current study demonstrates that both the levels of IL-2, IFN-γ, and IL-10 and the number of cells producing IL-2 and IFN-γ were lower at 2 and 4 weeks postinfection (p.i.) in aged compared to young mice after virus-specific stimulation of spleen cells
in vitro. In both age groups, IL-2 and IL-10 were produced by CD4
+ T and B cells, respectively. IFN-γ was produced mainly by CD4
+ T cells at 2 weeks p.i. and by CD4
+ and CD8
+ T cells at 4 weeks p.i. in young, but primarily by CD8
+ T cells, in aged mice. Therefore, delayed virus clearance is associated with age-related decreases in type 1 and type 2 cytokines and a shift in the primary source of at least one cytokine.
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Details
- Title
- Decreased IL-2, IFN-γ, and IL-10 Production by Aged Mice During the Acute Phase of E55+ Retrovirus Infection
- Creators
- Mohamed Elrefaei - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, PennsylvaniaKenneth J Blank - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, PennsylvaniaDonna M Murasko - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania
- Publication Details
- Virology (New York, N.Y.), v 299(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000177524800002
- Scopus ID
- 2-s2.0-0036039626
- Other Identifier
- 991014877689104721
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- Web of Science research areas
- Virology