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Journal article
Decreased Vancomycin Susceptibility of Coagulase-Negative Staphylococci in a Neonatal Intensive Care Unit: Evidence of Spread of Staphylococcus warneri
Journal of clinical microbiology, v 41(10), pp 4660-4665
01 Oct 2003
PMID: 14532199
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Coagulase-negative staphylococci (CoNS) are important pathogens in premature neonates; decreasing glycopeptide susceptibility has been observed among these isolates. The epidemiology of colonization with CoNS, the organisms' vancomycin susceptibilities, and genetic relatedness were studied over 6 months in a tertiary-care neonatal unit. A total of 321 isolates of CoNS were isolated. Seventy-five percent of the infants were colonized at admission, and virtually all were colonized thereafter. Common species were
Staphylococcus epidermidis
(69%),
S. warneri
(12%),
S. haemolyticus
(9.7%), and
S. hominis
(5.6%). A total of 3.9% of CoNS isolates had decreased vancomycin susceptibility (DVS) (MICs > 2.0 μg/ml); isolate recovery was associated with a stay in a neonatal intensive care unit for >28 days (
P
= 0.039), vancomycin exposure (
P
= 0.021), and
S. warneri
colonization (
P
< 0.0001). Nine of 12 (75%) CoNS with DVS were
S. warneri
, had enhanceable high-level resistance in vitro, were indistinguishable or closely related by pulsed-field gel electrophoresis, and were different from 29 vancomycin-susceptible
S. warneri
isolates. Epidemiological analysis suggested unsuspected nosocomial spread. Species determination in certain settings may aid in the understanding of emerging nosocomial problems.
Metrics
Details
- Title
- Decreased Vancomycin Susceptibility of Coagulase-Negative Staphylococci in a Neonatal Intensive Care Unit: Evidence of Spread of Staphylococcus warneri
- Creators
- Kimberly J. Center - St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, Pennsylvania, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School at Camden, Camden, New JerseyAnnette C. Reboli - University of Medicine and Dentistry of New JerseyRobin Hubler - St. Christopher's Hospital for ChildrenGail L. Rodgers - St. Christopher's Hospital for ChildrenSarah S. Long - St. Christopher's Hospital for Children
- Publication Details
- Journal of clinical microbiology, v 41(10), pp 4660-4665
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000185922900027
- Scopus ID
- 2-s2.0-0141958268
- Other Identifier
- 991019335241204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology