Logo image
Back
Decreases in macrophage mediated antitumor activity with aging
Journal article   Peer reviewed

Decreases in macrophage mediated antitumor activity with aging

Paul K. Wallace, Toby K. Eisenstein, Joseph J. Meissler and Page S. Morahan
Mechanisms of ageing and development, v 77(3), pp 169-184
1995
DOI: https://doi.org/10.1016/0047-6374(94)01524-P
PMID: 7739265
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Aging Biological response modifiers Immunotherapy Interferon Macrophage
We have demonstrated that immunotherapy of young (6–10 weeks old), and aged, (greater than 24 months old), tumor bearing mice with biological response modifiers enhanced survival and inhibited tumor growth, while treatment of aged mice had little or no effect. We hypothesized that the antitumor activity in young mice was principally mediated by activated macrophages (Mφ) and predicted that the change in aged mice was caused by an intrinsic Mφ defect which develops with advancing age. To directly test our hypothesis, we examined the antitumor activity of resident peritoneal Mφ, purified and activated in vitro with IFN γ plus LPS. Paralleling the results seen in vivo, Mφ from aged mice exhibited reduced antitumor activity in comparison with Mφ from younger mice. Moreover, there was reduced capacity of in vitro activated Mφ from aged mice to produce TNF, IL-1 and nitric oxide, which are critical monokines and effector molecules that have been established to either directly inhibit tumor growth or cause tumor cell destruction. These studies establish that peritoneal Mφ from aged mice have an intrinsic defect which prevents them from fully expressing their antitumor potential.

Metrics

8 Record Views
37 citations in Web of Science
39 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Cell Biology
Geriatrics & Gerontology
Logo image