Journal article
Deep Brain Stimulation – Therapeutic Possibilities in Alzheimer's Disease
OBM Geriatrics, v 5(2), pp 1-15
30 Apr 2021
Abstract
Alzheimer’s Disease (AD) is the leading cause of dementia worldwide, and represents a significant cause of cognitive decline, disability, and mortality. Ongoing clinical trials continue to investigate β-amyloid targeted therapy with unclear benefit, and we are currently limited to symptomatic treatment. Therefore, there is a salient need for the development of novel, potentially disease-modifying therapeutic strategies such as deep brain stimulation. This manuscript reviews Deep Brain Stimulation in Alzheimer’s Disease, describing the pathophysiology of the disease in terms of disordered neural circuitry, and a detailed discussion on trails of stimulation of the fornix, the nucleus basalis of Meynert and the ventral striatum/ventral capsule for the treatment of this dementia.
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Details
- Title
- Deep Brain Stimulation – Therapeutic Possibilities in Alzheimer's Disease
- Creators
- Ethan Fitzgerald - Drexel UniversityDorian Mateusz Kusyk (Corresponding Author) - Allegheny Health NetworkNestor D Tomycz - Allegheny Health Network
- Publication Details
- OBM Geriatrics, v 5(2), pp 1-15
- Publisher
- LIDSEN Publishing Inc.
- Number of pages
- 15
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Neurology
- Other Identifier
- 991022172662104721