Journal article
Deep Brain Stimulation for Psychiatric Diseases: A Pooled Analysis of Published Studies Employing Disease-Specific Standardized Outcome Scales
Stereotactic and functional neurosurgery, v 91(6), pp 345-354
01 Jan 2013
PMID: 24107902
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Deep brain stimulation (DBS) has emerged in recent years as a novel therapy in the treatment of refractory psychiatric disease, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and burette's syndrome (TS). Standardized outcome scales were crucial in establishing that DBS was an effective therapy for movement disorders. Objective: In order to better characterize the evidence supporting DBS for various psychiatric diseases, we performed a pooled analysis of those studies which incorporated specific standardized rating scales. Methods: A Medline search was conducted to identify all studies reporting DBS for MDD, OCD, and TS. The search yielded a total of 49 articles, of which 24 were included: 4 related to MDD (n = 48), 10 to OCD (n = 64), and 10 to TS (n = 46). Results: A meta-analysis of DBS for MDD, OCD, and TS in studies employing disease-specific standardized outcome scales showed that the outcome scales all improved in a statistically significant fashion for these psychiatric diseases. Our pooled analysis suggests that DBS for TS has the highest efficacy amongst the psychiatric diseases currently being treated with DBS, followed by OCD and MDD. Conclusion: DBS for psychiatric diseases remains investigational; however, even when studies failing to incorporate standardized outcome scales are excluded, there is statistically significant evidence that DBS can improve symptoms in MDD, OCD, and TS. Standardized disease-specific outcome scales facilitate pooled analysis and should be a required metric in future studies of DBS for psychiatric disease. (C) 2013 S. Karger AG, Basel
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Details
- Title
- Deep Brain Stimulation for Psychiatric Diseases: A Pooled Analysis of Published Studies Employing Disease-Specific Standardized Outcome Scales
- Creators
- Raj Nangunoori - Allegheny General HospitalNestor D. Tomycz - Allegheny General HospitalMatthew Quigley - Allegheny General HospitalMichael Y. Oh - Allegheny General HospitalDonald M. Whiting - Allegheny Gen Hosp, Dept Neurosurg, Pittsburgh, PA 15212 USA
- Publication Details
- Stereotactic and functional neurosurgery, v 91(6), pp 345-354
- Publisher
- Karger
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration; Surgery
- Web of Science ID
- WOS:000327052100001
- Scopus ID
- 2-s2.0-84885081093
- Other Identifier
- 991021448054804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Surgery