Journal article
Deep brain stimulation for appetite disorders: a review
Neurosurgical focus, v 45(2), pp E9-E9
01 Aug 2018
PMID: 30064311
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The mechanisms of appetite disorders, such as refractory obesity and anorexia nervosa, have been vigorously studied over the last century, and these studies have shown that the central nervous system has significant involvement with, and responsibility for, the pathology associated with these diseases. Because deep brain stimulation has been shown to be a safe, efficacious, and adjustable treatment modality for a variety of other neurological disorders, it has also been studied as a possible treatment for appetite disorders. In studies of refractory obesity in animal models, the ventromedial hypothalamus, the lateral hypothalamus, and the nucleus accumbens have all demonstrated elements of success as deep brain stimulation targets. Multiple targets for deep brain stimulation have been proposed for anorexia nervosa, with research predominantly focusing on the subcallosal cingulate, the nucleus accumbens, and the stria terminalis and medial forebrain bundle. Human deep brain stimulation studies that focus specifically on refractory obesity and anorexia nervosa have been performed but with limited numbers of patients. In these studies, the target for refractory obesity has been the lateral hypothalamus, ventromedial hypothalamus, and nucleus accumbens, and the target for anorexia nervosa has been the subcallosal cingulate. These studies have shown promising findings, but further research is needed to elucidate the long-term efficacy of deep brain stimulation for the treatment of appetite disorders.
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Details
- Title
- Deep brain stimulation for appetite disorders: a review
- Creators
- Alexander C. Whiting - St. Joseph's Hospital and Medical CenterMichael Y. Oh - Allegheny Health NetworkDonald M. Whiting - Allegheny Health Network
- Publication Details
- Neurosurgical focus, v 45(2), pp E9-E9
- Publisher
- Amer Assoc Neurological Surgeons
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:000440488900009
- Scopus ID
- 2-s2.0-85051058394
- Other Identifier
- 991021448052304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery