Journal article
Deep brain stimulation for obesity--from theoretical foundations to designing the first human pilot study
Neurosurgical review, v 35(1)
Jan 2012
PMID: 21996938
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Obesity is perhaps an evolutionary consequence of a species reared with intermittent caloric reward. Humans are hardwired to enjoy food, and our bodies voraciously extract and store energy from food as if each meal was the last. As an amalgam of behavioral and metabolic disturbance, obesity is an attractive target for deep brain stimulation (DBS) since neuromodulation may be able to influence both eating behavior and metabolism. The current pandemic proportions of obesity combined with the failures and morbidity of modern treatments remain the impetus behind the application of DBS to this complex disease. We review the rationale and scientific foundations for obesity DBS and explain how this preclinical evidence has helped sculpt the design of the first human pilot study.
Metrics
Details
- Title
- Deep brain stimulation for obesity--from theoretical foundations to designing the first human pilot study
- Creators
- Nestor D Tomycz - Allegheny General HospitalDonald M Whiting - Allegheny General HospitalMichael Y Oh - Allegheny General Hospital
- Publication Details
- Neurosurgical review, v 35(1)
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:000301665100007
- Scopus ID
- 2-s2.0-84862626910
- Other Identifier
- 991021448180004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Surgery