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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Deficits in Concept Formation in Amyotrophic Lateral Sclerosis
Neuropsychology, v 26(4), pp 422-429
01 Jul 2012
PMID: 22612577
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: Amyotrophic Lateral Sclerosis (ALS) is associated with impaired executive control. The aim of the current research was to test the hypothesis that concept formation deficits associated with an extramotor neurocognitive network involving executive and semantic resources can be found in some ALS patients. Method: Forty-one patients with clinically definite ALS were assessed with Delis Kaplan Executive Function System Sorting Test (D-KEFS), a measure of concept formation requiring patients to manipulate verbal and visual semantic information and neuropsychological tests measuring naming, semantic memory, and executive control. Using D-KEFS scale scores, a k-mean cluster analysis specifying a 3-group solution was able to classify ALS patients into groups presenting with mildly impaired, average, and above average sorting test performance. High-resolution T1 structural MRI was used to examine cortical thickness in a subset of 16 ALS patients. Results: Stepwise regression analyses related free and recognition sorting test performance to measures of action naming, single word semantic knowledge, and mental search/working memory. MRI studies found widespread cortical thinning involving bilateral frontal, temporal, and parietal regions. Regression analyses related recognition sorting performance to reduced MRI cortical thickness involving the left prefrontal and left parietal cortex. Conclusions: An extramotor cognitive network is associated with impaired concept formation in ALS.
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Details
- Title
- Deficits in Concept Formation in Amyotrophic Lateral Sclerosis
- Creators
- David J. Libon - Drexel UniversityCorey McMillan - College Station Medical CenterBrian Avants - College Station Medical CenterAshley Boller - College Station Medical CenterBrianna Morgan - College Station Medical CenterLisa Burkholder - College Station Medical CenterKeerthi Chandrasekaran - College Station Medical CenterLauren Elman - College Station Medical CenterLeo McCluskey - College Station Medical CenterMurray Grossman - College Station Medical Center
- Publication Details
- Neuropsychology, v 26(4), pp 422-429
- Publisher
- Amer Psychological Assoc
- Number of pages
- 8
- Grant note
- R01NS044266 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) P01AG017586 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) AG32953; AG17586; AG15116; NS44266; NS53488 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000306036300003
- Scopus ID
- 2-s2.0-84874031550
- Other Identifier
- 991021901313604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Psychology
- Psychology, Clinical