Journal article
Defining the Values and Quality of Life of Cancer Survivors Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: An International Survey Study
Annals of surgical oncology, v 30(12), pp 7825-7832
01 Nov 2023
PMID: 37535272
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
Advances in treatment of peritoneal surface malignancies including cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS & PLUSMN;HIPEC) have led to long-term survivorship, yet the subsequent quality of life (QOL) and values of these patients are unknown.
Patients and Methods
Survivors were offered surveys via online support groups. Novel items assessed how patients prioritized experience, costs, longevity, and wellbeing.
Results
Of the 453 gastrointestinal/hepatobiliary (GI/HPB) surgical patients that responded, 74 underwent CRS & PLUSMN;HIPEC and were 54 & PLUSMN;12 years old, 87% female, and 93% white. Respondents averaged 29 months from diagnosis, with a maximum survival of 20 years. With a moderate level of agreement (W = 39%), rankings of value metrics among respondents were predictable (p < 0.001). Longevity and functional independence were ranked highest; treatment experience and cost of treatment were ranked lowest (p < 0.001). Those who underwent CRS & PLUSMN;HIPEC or other GI/HPB surgeries reported the same rank order. QOL in CRS & PLUSMN;HIPEC survivors, both mental (M-QOL) (44 & PLUSMN;13) and physical (P-QOL) (41 & PLUSMN;11) were lower than in the general population (50 & PLUSMN;10); p < 0.001. Impairments persisted throughout survivorship, but M-QOL improved over time (p < 0.05). When comparing CRS & PLUSMN;HIPEC with other GI/HPB cancer surgery survivors, M-QOL (43 & PLUSMN;13 versus 43 & PLUSMN;14, p = 0.85) and P-QOL (40 & PLUSMN;11 versus 42 & PLUSMN;12, p = 0.41) were similar.
Conclusions
Although CRS & PLUSMN;HIPEC survivors experience long-term mental and physical health impairments, they were similar to those experienced by survivors of other GI/HPB cancer surgeries, and their QOL improved significantly throughout survivorship. As CRS & PLUSMN;HIPEC survivors prioritize longevity above all other metrics, survival benefit may outweigh a temporary reduction in QOL.
Metrics
Details
- Title
- Defining the Values and Quality of Life of Cancer Survivors Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: An International Survey Study
- Creators
- Chelsea M. Knotts - West Virginia UniversityMayar A. Osman - Drexel UniversityAderinsola A. Aderonmu - Drexel UniversityNathan Bahary - Drexel University, General Internal MedicinePatrick L. Wagner - Drexel University, SurgeryDavid L. Bartlett - Drexel University, SurgeryCasey J. Allen - Allegheny Health Network
- Publication Details
- Annals of surgical oncology, v 30(12), pp 7825-7832
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- Highmark Health (Pittsburgh, PA, USA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Surgery; General Internal Medicine
- Web of Science ID
- WOS:001042679800001
- Scopus ID
- 2-s2.0-85166517569
- Other Identifier
- 991021861202604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Surgery