Journal article
Definitive radiation therapy for endometrial cancer in medically inoperable elderly patients
Brachytherapy, v 9(3), pp 260-265
01 Jul 2010
PMID: 20122872
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
PURPOSE: With the increasing elderly population, more women with newly diagnosed endometrial cancer may not be surgical candidates due to medical comorbidities. Definitive radiation therapy with external beam radiation (EBRT) and/or brachytherapy is a reasonable primary treatment for endometrial cancer in patients who cannot undergo surgery.
METHODS: A retrospective review identified 26 women 75 years and older with endometrial cancer who were not operative candidates due to comorbidities and received definitive radiation.
RESULTS: The median age of the treated patients was 83, all of whom had significant medical comorbidities precluding surgical treatment. Seventy-three percent of the patients had stage T1 disease, 19% were stage T2, and 8% were stage T3. Seventy-three percent of patients received EBRT before brachytherapy (median dose: 45 Gy). The median brachytherapy dose was 20 Gy in 5 fractions. The types of brachytherapy used were Rotte Y applicator (42%), tandem and cylinder (42%), and ring and tandem (16%). Median followup was 12 months (1-60 months). No treatment breaks were required for the entire group and only 2 patients (8%) developed late toxicity. The overall survival for all patients was 89% and 28% at 1 and 2 years, respectively. Disease-specific survival for all patients was 93% at 1 year and 73% at 3 years.
CONCLUSIONS: The results in this study indicate that definitive radiation with EBRT and/or brachytherapy for endometrial cancer is feasible and well tolerated in an elderly population. (C) 2010 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
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Details
- Title
- Definitive radiation therapy for endometrial cancer in medically inoperable elderly patients
- Creators
- Rodney E. Wegner - Magee-Womens HospitalSushil Beriwal - Magee-Womens HospitalDwight E. Heron - Magee-Womens HospitalScott D. Richard - UPMC Hillman Cancer CenterJoseph L. Kelly - UPMC Hillman Cancer CenterRobert P. Edwards - UPMC Hillman Cancer CenterPaniti Sukumvanich - UPMC Hillman Cancer CenterKristin K. Zorn - UPMC Hillman Cancer CenterThomas C. Krivak - UPMC Hillman Cancer Center
- Publication Details
- Brachytherapy, v 9(3), pp 260-265
- Publisher
- Elsevier
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); Obstetrics and Gynecology
- Web of Science ID
- WOS:000280828700016
- Scopus ID
- 2-s2.0-77954956906
- Other Identifier
- 991021897256804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging